Results 61 to 70 of about 183,323 (251)

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Driver Behavior-Driven Evacuation Strategy with Dynamic Risk Propagation Modeling for Road Disruption Incidents

open access: yesEng
When emergency incidents, such as bridge damage, abruptly occur on highways and lead to traffic disruptions, the multidimensionality and complexity of driver behaviors present significant challenges to the design of effective emergency response ...
Yanbin Hu, Wenhui Zhou, Hongzhi Miao
doaj   +1 more source

Propagation-based phase-contrast synchrotron imaging of aortic dissection in mice : from individual elastic lamella to 3D analysis [PDF]

open access: yes, 2018
In order to show the advantage and potential of propagation-based phase-contrast synchrotron imaging in vascular pathology research, we analyzed aortic medial ruptures in BAPN/AngII-infused mice, a mouse model for aortic dissection. Ascending and thoraco-
Aoki, Hiroki   +8 more
core   +3 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Conditional recovery of time-reversal symmetry in many nucleus systems

open access: yesNew Journal of Physics, 2019
The propagation of non-topological solitons in many-nucleus systems is studied based on time-dependent density functional calculations, focusing on mass and energy dependence.
Yoritaka Iwata, Paul Stevenson
doaj   +1 more source

Three-dimensional magnetohydrodynamical simulations of the morphology of head-tail radio galaxies based on magnetic tower jet model

open access: yes, 2017
The distinctive morphology of head-tail radio galaxies reveals strong interactions between the radio jets and their intra-cluster environment, the general consensus on the morphology origin of head-tail sources is that radio jets are bent by violent ...
Gan, Zhaoming   +3 more
core   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman   +9 more
wiley   +1 more source

Propagation of a Precessing Jet in the Envelope of Tidal Disruption Events

open access: yesThe Astrophysical Journal
It is likely that the disk of a tidal disruption event (TDE) is misaligned with respect to the equatorial plane of the spinning supermassive black hole (SMBH), since the initial stellar orbit before disruption most likely has an inclined orbital plane ...
Hao-Yu Yuan, Hong-Zhou Wu, Wei-Hua Lei
doaj   +1 more source

Indirect Dark Matter Signals from EGRET and PAMELA compared

open access: yes, 2009
Dark Matter annihilation (DMA) may yield an excess of gamma rays and antimatter particles, like antiprotons and positrons, above the background from cosmic ray interactions.
David B. Cline, Wim de Boer
core   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang   +22 more
wiley   +1 more source

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