Results 51 to 60 of about 183,323 (251)

Indirect mapping of the source of the oppositely directed fast plasma flows in the plasma sheet onto the auroral display [PDF]

Annales Geophysicae, 2006
Data from Polar and Geotail spacecraft are combined to investigate the relationship between locations of active auroras and the magnetotail plasma sheet region where reversed fast plasma flows are generated during substorms.
A. G. Yahnin, I. V. Despirak, A. A. Lubchich, B. V. Kozelov, N. P. Dmitrieva, M. A. Shukhtina, H. K. Biernat   +6 more
doaj   +1 more source

Systems and methods for altering visual acuity [PDF]

, 2012
Provided are systems operable to effect a temporary change in a modulation transfer function (MTF) of a target imaging system. The systems include a light source operable to produce light for transient propagation onto at least a portion of the target ...
Milner, Thomas E., Rylander, Henry Grady, III, Vincelette, Rebecca L., Welch, Ashley J.   +3 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Complex delay dynamics on railway networks: from universal laws to realistic modelling

, 2018
Railways are a key infrastructure for any modern country. The reliability and resilience of this peculiar transportation system may be challenged by different shocks such as disruptions, strikes and adverse weather conditions. These events compromise the
di Clemente, Riccardo, Gravino, Pietro, Monechi, Bernardo, Servedio, Vito D. P.   +3 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Ultralow radiant exposure of a short-pulsed laser to disrupt melanosomes with localized thermal damage through a turbid medium

Scientific Reports
Short-pulsed lasers can treat dermal pigmented lesions through selective photothermolysis. The irradiated light experiences multiple scattering by the skin and is absorbed by abnormal melanosomes as well as by normal blood vessels above the target ...
Yu Shimojo, Takahiro Nishimura, Daisuke Tsuruta, Toshiyuki Ozawa   +3 more
doaj   +1 more source

Towards Structure-Guided Development of Pain Therapeutics Targeting Voltage-Gated Sodium Channels

Frontiers in Pharmacology, 2022
Voltage-gated sodium (NaV) channels are critical molecular determinants of action potential generation and propagation in excitable cells. Normal NaV channel function disruption can affect physiological neuronal signaling and lead to increased ...
Phuong T. Nguyen, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

On the interaction of jets with stellar winds in XRBs

, 2010
We present the first three-dimensional simulations of the evolution of a microquasar jet inside the binary-star system. The aim is to study the interaction of these jets with the stellar wind from a massive companion and the possible locations of high ...
Bosch-Ramon, V., Khangulyan, D., Perucho, M.   +2 more
core   +1 more source