Results 131 to 140 of about 193,431 (315)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Metasurfaces and Metadevices for Topological Electromagnetic Waves

Advanced Physics Research
Metamaterials and metasurfaces recently provided platforms for integrated and compact generation of structured light fields and nontrivial electromagnetic phenomena.
Rensheng Xie, Nilo Mata‐Cervera, Xi Xie, Yijie Shen   +3 more
doaj   +1 more source

Assessing the feasibility of CRISPRa approaches to enhance protein-based biomaterial expression in bacterial systems for more efficient production

Materials Today Bio
Recombinant protein production is crucial for biomedical and industrial applications; however, achieving high yields for complex protein-like biomaterials such as elastin-like recombinamers (ELRs) remains challenging. ELRs, protein-based polymers derived
Pablo Rodríguez-Alonso, Viktoriya Chaskovska, Desiré Venegas-Bustos, Alba Herraiz, Matilde Alonso, Jose Carlos Rodríguez-Cabello   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Topological robustness of classical and quantum optical skyrmions in atmospheric turbulence

Nature Communications
The degradation of classical and quantum structured light induced by complex media, such as atmospheric turbulence, constitutes a critical barrier to its practical implementation in communication, energy transport, imaging and sensing.
Zhenyu Guo, Cade Peters, Nilo Mata-Cervera, Anton N. Vetlugin, Ruixiang Guo, Pei Zhang, Andrew Forbes, Yijie Shen   +7 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Does Virtual Prototyping Kill the Potential for Disruptive Innovation?

, 2007
A critical element of a corporate entrepreneur’s opportunity evaluation process will involve the attempt to understand customer requirements in order to calculate commercial demand.
Jacobs, Joanne, Thomond, Pete
core  

Disruptive Behavior

, 2016
Misbehavior and disruption in the operating room are an all too common problem. Disruptive behaviors have been observed and experienced by all members of the operating room team, and these behaviors need to be addressed in a timely and appropriate ...
David J. Birnbach, Sheri A. Keitz
core   +1 more source

How disruptive are disruptive operators?

, 2018
The issue of disruptive operators has recently gained interest among researchers and regulators. From a regulator's perspective, disruptive operators can increase competitive rivalry in markets dominated by a handful of large companies, thus allowing ...
Parisot, Xavier, Vialle, Pierre, Parisot, Xivier, Whalley, Jason   +3 more
core   +1 more source

Higher-order spatiotemporal wave packets with Gouy phase dynamics

Nanophotonics
Spatiotemporal (ST) wave packets constitute a broad class of optical pulses whose spatial and temporal degrees of freedom cannot be treated independently.
Yu Wangke, Shen Yijie
doaj   +1 more source