Results 61 to 70 of about 193,431 (315)
eLife, 2013 Cachexia, a condition that kills about one-fifth of cancer patients, may be linked to Rb—a protein that is already linked to various cancers—moving from the cell nucleus to the cytoplasm.
Giulio Cossu +2 more
openaire +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Disruptive Change in Today’s Innovation: A Case Study Analysis of OptimalPlus [PDF]
, 2019 In today’s hypercompetitive world, electronics manufacturing companies experience challenges to respond to increasing consumer electronics demand while combatting disruptive change in their industries. The revolution in manufacturing via Industry 4.0 has
Daryl D. Green +4 more
core +1 more source
Foresight and STI Governance, 2020 The tobacco industry worldwide has annual revenues of hundreds of billions of dollars, and annual smoking-associated death rates in the millions. Electronic cigarettes designed as a less harmful alternative to traditional tobacco products allow users to inhale nicotine, without consuming the products of burning tobacco, thus significantly lowering ...
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Scientific Reports, 2021 Gelatin methacryloyl (GelMA) is one of the most widely used photo-crosslinkable biopolymers in tissue engineering. In in presence of an appropriate photoinitiator, the light activation triggers the crosslinking process, which provides shape fidelity and ...
Sina Sharifi +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Accounting for disruptive developments in strategic planning of shipping in the Arctic. Background Paper 5/2021. [PDF]
, 2021 The changing climate gradually opens the way to the Arctic waters for commercial shipping. This requires long-term investments in infrastructure and hence strategic planning of shipping activities both by governments and the global maritime industry to ...
Strelkovskii, N. +2 more
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source