Results 51 to 60 of about 122,020 (295)
Heliyon, 2023 Early adolescence is a crucial time for understanding and detecting the risk factors that may influence youth externalizing/disruptive behaviors and disorders.
Tuana Kant +5 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Comorbid Obsessive Compulsive Disorder in a Child with Tuberous Sclerosis Complex
Psychiatry and Behavioral Sciences, 2018 Tuberous sclerosis complex (TSC) is a genetic disease that mostly affects the brain, skin, kidneys, eyes, heart and lungs. Various neuropsychiatric comorbidities such as mental retardation, mood disorders, anxiety disorders, disruptive/ aggressive ...
Borte Gurbuz Ozgur +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Prosocial skills may be necessary for better peer functioning in children with symptoms of disruptive behavior disorders [PDF]
PeerJ, 2014 Children with disruptive behavior disorders experience substantial social challenges; however, the factors that account for (i.e., mediate), or influence (i.e., moderate), peer problems are not well understood.
Brendan F. Andrade +2 more
doaj +2 more sources
Serotonin and motherhood: From molecules to mood [PDF]
, 2019 Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin, in the display of maternal behaviors and reproduction-associated plasticity in the maternal brain.
Li, Ming +2 more
core +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
NeurogliaNeurodevelopmental disorders represent a significant health concern, leading to a wide range of clinical, cognitive, and social impairments. Although the exact causes of these disorders remain unclear, genetic, epigenetic, and environmental factors all ...
Samet Çetin +5 more
doaj +1 more source
BMC Psychiatry, 2008 Background Pharmacological and genetic studies suggest the importance of the dopaminergic, serotonergic, and noradrenergic systems in the pathogenesis of Attention Deficit Hyperactivity Disorder (ADHD) and Disruptive Behavior Disorder (DBD).
Larsson Jan-Olov +4 more
doaj +1 more source