Results 71 to 80 of about 185,290 (300)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Using differential reinforcement for all to manage disruptive behaviors: three class interventions at kindergarten and primary school

open access: yesFrontiers in Education
IntroductionDisruptive behaviors produce harmful effects, which reduce students’ well-being and learning opportunities. This paper presents a new strategy named Differential Reinforcement for All (DR-All), which has been inspired by DR and Social ...
Pascal Pansu   +3 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Yoga and Its Influence on Children\u27s Behavior [PDF]

open access: yes, 2018
This study looked at the impact ten minutes of daily yoga had on the behavior of elementary school children. Yoga was led by classroom teachers once daily for ten minutes over a sixteen-week period.
Sellen, Paige
core   +1 more source

Living Innovation Laboratory Model Design and Implementation

open access: yes, 2015
Living Innovation Laboratory (LIL) is an open and recyclable way for multidisciplinary researchers to remote control resources and co-develop user centered projects.
Zheng, Yuting
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The Education and Miseducation of Boys in Cultural, Political, and Christian Perspective [PDF]

open access: yes, 2010
The trend of higher male achievement at of all levels of education has reversed in the last twenty years, in almost every major country except Japan, sparking global political and social debate about this intriguing phenomenon.
Bulgin, Roseclaire   +1 more
core   +1 more source

The MHD Kelvin-Helmholtz Instability II: The Roles of Weak and Oblique Fields in Planar Flows [PDF]

open access: yes, 1997
We have carried out high resolution MHD simulations of the nonlinear evolution of Kelvin-Helmholtz unstable flows in 2 1/2 dimensions. The modeled flows and fields were initially uniform except for a thin shear layer with a hyperbolic tangent velocity ...
Adam Frank   +8 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Qualitative Assessment of the PAX Good Behavior Game Implementation [PDF]

open access: yes, 2019
This paper reports on a program evaluation of the PAX Good Behavior Game (GBG), an evidence-based practice intervention designed to create a nurturing environment conducive to learning in elementary schools.
Kinney, Samantha   +3 more
core   +1 more source

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