Results 101 to 110 of about 219,079 (300)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Mathematical Simulations and On-Road Experimentations of the Vibration Energy Harvesting from Mining Dump Truck Hydro-Pneumatic Suspension

open access: yesShock and Vibration, 2019
Running on an unpaved road, the truck’s vibration is weakened by the HPS (hydro-pneumatic suspension) and transformed into thermal energy which was finally dissipated in the air.
Wenguang Wu, Sha Zhang, Zhiyong Zhang
doaj   +1 more source

Damping of double wall panels including a viscothermal air layer [PDF]

open access: yes, 2001
This paper deals with the dynamic behaviour of double wall panels, with emphasis on damping and sound radiation. It will be shown that a narrow air layer separating the two plates of a panel significantly alters the mentioned quantities by its ...
Basten, T.G.H.
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

ENERGY DISSIPATION IN TIDAL ESTUARIES

open access: yesCoastal Engineering Proceedings, 1976
In this study, the method for damped co-oscillating tides is used to evaluate damping and energy dissipation characteristics for various estuaries of different geometry and depth. Of special interest are the damping and energy dissipation characteristics of the German tidal rivers such as Elbe, Weser and Ems in comparison with North-American tidal ...
Hans-Werner Partenscky, Günther Barg
openaire   +2 more sources

Thermal Detection of Turbulent and Laminar Dissipation in Vortex Front Motion

open access: yes, 2012
We report on direct measurements of the energy dissipated in the spin-up of the superfluid component of 3He-B. A vortex-free sample is prepared in a cylindrical container, where the normal component rotates at constant angular velocity.
A.P. Finne   +35 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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