Results 91 to 100 of about 709,863 (314)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
The relationship of dissociation to borderline and schizotypal personality syndromes
, 2001 Borderline and schizotypal personality constructs were compared as predictors of dissociation for 971 nonclinical university undergraduates who completed 11 self-report behavior inventories.
Stockdale, Gary D.
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The effect of temperature on the oxygen dissociation curves of whole blood of larval and adult lampreys (Geotria australis) [PDF]
, 1982 Oxygen dissociation curves of the whole blood of larvae and adults of the Southern Hemisphere lamprey Geotria australis have been determined between pH 6.8 and 8.2 at 5, 15 and 25 degrees C. 2. The P50's at temperatures of 5, 15 and 25 degrees C and a pH
Macey, D.J., Potter, I.C.
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
, 2011 Dissociation is the first step to obtain a sufficient number of spermatogonia as donor cells for transplantation. Dissociation techniques is perfomed by mechanical and enzymatic methods to accelerate the separation of cells and tissue.
Syahrani, Nurida Dessalma
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
European Journal of Psychotraumatology, 2016 Background: Patients with posttraumatic stress disorder (PTSD) are prone to dissociation, which in theory should interfere with successful treatment. However, most empirical studies do not substantiate this assumption.
Nikolaus Kleindienst +8 more
doaj +1 more source
Partial Dissociation and Hydration Quantitatively Explain the Properties of Aqueous Electrolyte Solutions and hence Empirical Activity Concepts are Unnecessary [PDF]
, 2011 The author shows that Arrhenius's theory of partial electrolytic dissociation was immaturely displaced about eight decades ago by the empirical concept of ionic activities and the assumption of complete dissociation of electrolytes at all ...
Raji Heyrovska
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