Results 101 to 110 of about 644,654 (317)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Dissociation, postraumática stress symptoms, emotional dysregulation, and invalidating environments as correlativo of ósea in borderline personality disorder patients [PDF]
Theoretical models have proposed that inadequate caregiving environments undermine the development of adaptive regulation strategies at early stages and can lead children to inadequate regulation skills for coping with distress, such as dissociation ...
Pérez Rodríguez, Sandra +2 more
core +1 more source
Numerical simulation on the marine landslide due to gas hydrate dissociation [PDF]
, 2017 Marine landslide due to gas hydrate dissociation is a kind of potential heavy hazards. Numerical simulation was processed to investigate the deformation landslide and effects of main factors on the critical scale of dissociation zone to induce marine ...
Lu L +4 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Mechanism of soil stratum instability induced by hydrate dissociation [PDF]
, 2016 Gas hydrate dissociation may lead to soil stratum instability such as marine landslides in hydrate-bearing sediments. In this paper, centrifugal tests were conducted to investigate the soil responses and stratum instability of a 14 degrees slope during ...
Zhang LM +5 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
WanchengBao/Simulations-of-proton-dissociation-using-OH-functionalized-GQDs: v1.0.2 [PDF]
<p>this is the second</p> <p><strong>Full Changelog</strong>: https://github.com/WanchengBao/Simulations-of-proton-dissociation-using-OH-functionalized-GQDs/compare/v1.0.0...v1.0.1</p ...
WanchengBao
core +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
European Journal of Psychotraumatology, 2016 Background: Patients with posttraumatic stress disorder (PTSD) are prone to dissociation, which in theory should interfere with successful treatment. However, most empirical studies do not substantiate this assumption.
Nikolaus Kleindienst +8 more
doaj +1 more source