Results 61 to 70 of about 642,202 (317)

Biomarkers of dissociation

BJPsych Open, 2023
Summary Dissociative symptoms present transdiagnostically and are related to poor clinical outcome. Research into the biological correlates of dissociation remains limited. This editorial summarises and discusses papers from this themed series of BJPsych Open that contribute to unravelling the biological correlates of dissociative symptomatology ...
Antje A. T. S. Reinders, Allan H. Young, Dick J. Veltman   +2 more
openaire   +4 more sources

A survey of dissociation, boundary-thinness, and psychological wellbeing in spiritualist mental mediumship [PDF]

, 2011
The purpose of this study was to explore the personality and psychological wellbeing of Spiritualist mental mediums compared to nonmedium Spiritualists.
Roxburgh, EC, Roe, CA, Roe, Chris A, Roe, Chris A; id_orcid, Roxburgh, Elizabeth C   +4 more
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Early Images of Trauma in George Eliot’s The Lifted Veil

Humanities
This paper explores George Eliot’s The Lifted Veil (1859) as an early portrayal of traumatic neurosis, providing a fresh perspective to enhance the existing scholarly attention on trauma in Eliot’s Daniel Deronda.
Melissa Rampelli
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A Ligand-Dissociation-Involved Mechanism in Amide Formation of Monofluoroacylboronates with Hydroxylamines

, 2017
Acylborons, as a growing class of boron reagents, were successfully applied to amide ligation and showed potential in chemoselective bioconjugation reactions in recent years.
Yujie Liang (1519678), Chen Wang (88408), Xiaoping Man (3618338), Siwei Bi (1692427), Yao Fu (386864), Yuan-Ye Jiang (1642738)   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Methane release from warming-induced hydrate dissociation in the West Svalbard continental margin: timing, rates, and geological controls

, 2013
Hundreds of plumes of methane bubbles, first observed in 2008, emanate from an area of the seabed off West Svalbard that has become 1°C warmer over the past 30 years. The distribution of the plumes, lying close to and upslope from the present upper limit
Thatcher, K.E., Westbrook, G.K., Sarkar, S., Minshull, T.A.   +3 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source