Results 71 to 80 of about 1,227,945 (330)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Implicit self-esteem in borderline personality and depersonalization disorder

Frontiers in Psychology, 2012
Self-identity is disrupted in people with borderline personality disorder (BPD) and depersonalization disorder (DPD), fluctuating with sudden shifts in affect in BPD and experienced as detached in DPD.
Alexis eHedrick, Heather eBerlin
doaj   +1 more source

“If only he were blind”: Shame, trauma, and dissociation among women with body dysmorphic disorder in physically intimate relationships

International Journal of Qualitative Studies on Health & Well-Being, 2022
Background Body Dysmorphic Disorder (BDD) involves a debilitating preoccupation with one’s appearance and associated difficulties in social and interpersonal relationships, according to the Diagnostic and Statistical Manual for Mental Disorders (DSM-5 ...
Natalie Stechler, Isabel Henton
doaj   +1 more source

Dissociation and ionization of small molecules steered by external noise

, 2007
We show that ionization and dissociation can be influenced separately in a molecule with appropriate external noise. Specifically we investigate the hydrogen molecular ion under a stochastic force quantum mechanically beyond the Born-Oppenheimer ...
Anatole Kenfack, Frank Großmann, Hondou T, Hänggi P, Jan M Rost, Luczka J, Moss F, Posthumus J H   +7 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Mutual heavy ion dissociation in peripheral collisions at ultrarelativistic energies [PDF]

, 2001
We study mutual dissociation of heavy nuclei in peripheral collisions at ultrarelativistic energies. Earlier this process was proposed for beam luminosity monitoring via simultaneous registration of forward and backward neutrons in zero degree ...
A. Grünschloss, A. J. Baltz, A. J. Baltz, A. Leprêtre, A. Leprêtre, A. M. van den Berg, A. S. Iljinov, A. S. Iljinov, A. V. Ignatyuk, A. V. Ignatyuk, A. Ventura, A. Veyssière, B. L. Berman, B. L. Berman, C. A. Bertulani, C. A. Bertulani, C. Caso, C. J. Benesh, C. J. Benesh, E. Wolynec, F. Krauss, F. Tagliabue, G. A. Chekomazov, G. Baur, H. Dekhissi, I. A. Pshenichnov, I. A. Pshenichnov, I. A. Pshenichnov, I. N. Mishustin, J. C. Hill, J. D. Jackson, J. D. T. Arruda-Neto, J. Hüfner, J. P. Bondorf, J. P. Bondorf, J. W. Norbury, J.-J. Gaimard, K. Hencken, K. Hencken, L. F. Oliveira, M. B. Chadwick, M. B. Chadwick, M. Gazdzicki, N. Bianchi, P. G. Young, R. Alarcon, R. Engel, R. F. Askew, R. R. Harvey, S. Masetti, S. N. Beljaev, S. N. White, S. S. Dietrich, T. Aumann, V. Muccifora, V. V. Varlamov, W. J. Llope   +56 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Identity state‐dependent self‐relevance and emotional intensity ratings of words in dissociative identity disorder: A controlled longitudinal study

Brain and Behavior, 2023
Introduction Dissociative identity disorder (DID) is characterized by, among others, amnesic episodes and the recurrence of different dissociative identity states. While consistently observed in clinical settings, to our knowledge, no controlled research
Aikaterini I. Strouza, Andrew J. Lawrence, Eline M. Vissia, Andreana Kakouris, Ayse Akan, Ellert R. S. Nijenhuis, Nel Draijer, Sima Chalavi, Antje A. T. S. Reinders   +8 more
doaj   +1 more source

Hydrogen Dissociation and Diffusion on Ni and Ti -doped Mg(0001) Surfaces

, 2008
It is well known, both theoretically and experimentally, that alloying MgH$_2$ with transition elements can significantly improve the thermodynamic and kinetic properties for H$_2$ desorption, as well as the H$_2$ intake by Mg bulk.
A. Amieiro, A. Pratt, Ashcroft N. W., D. Alfè, Kittel C., Lide D. R., M. Pozzo, S. French   +7 more
core   +1 more source

The phase space geometry underlying roaming reaction dynamics [PDF]

, 2018
Recent studies have found an unusual way of dissociation in formaldehyde. It can be characterized by a hydrogen atom that separates from the molecule, but instead of dissociating immediately it roams around the molecule for a considerable amount of time ...
Krajnak, Vladimir, Waalkens, Holger
core   +5 more sources