Results 111 to 120 of about 1,577,920 (354)
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
, 2019 The fullerene C$_{60}$, one of the largest molecules identified in the interstellar medium (ISM), has been proposed to form top-down through the photo-chemical processing of large (more than 60 C-atoms) polycyclic aromatic hydrocarbon (PAH) molecules. In
Chen, Tao +5 more
core +1 more source
Oxygen Hydration Mechanism for the Oxygen Reduction Reaction at Pt and Pd Fuel Cell Catalysts [PDF]
, 2011 We report the reaction pathways and barriers for the oxygen reduction reaction (ORR) on platinum, both for gas phase and in solution, based on quantum mechanics calculations (PBE-DFT) on semi-infinite slabs. We find a new mechanism in solution: O_2 → 2O_(
Goddard, William A., III +4 more
core +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Chemistry, 2019 Svante Augustus Arrhenius (1859, Vik - 1927, Stockholm) received the Nobel Prize for Chemistry in 1903 "in recognition of the extraordinary services he rendered to the advancement of chemistry by his electrolytic theory of dissociation".
Justus Masa +3 more
semanticscholar +1 more source
Detection of interstellar SO(+) - A diagnostic of dissociative shock chemistry
The Astrophysical Journal, 1992 SO + , predicted to form efficiently by dissociative shocks (Neufeld & Dalgarno, 1989, ApJ, 340), has been detected in the shocked molecular clump IC 443G, by means of four transitions at 3 and 1.3 mm wavelength. Its large line width establishes its formation by shocks, and the physical conditions derived from statistical equilibrium calculations match
openaire +2 more sources
How Many Drugs Are Catecholics
Molecules, 2007 By examination of the 8659 drugs recorded in the Comprehensive Medicinal Chemistry (CMC) database, 78 catecholics (including five pyrogallolics) were identified, of which 17 are currently prescribed by FDA.
Da-Peng Yang +4 more
doaj +1 more source
Computational fluid dynamics and aerothermodynamics [PDF]
At the present time the efforts on this project are organized into two areas: the development of an approximate stagnation point solution and approximate flowfield studies which can be used to develop and investigate shock jump, electron temperature ...
Carlson, Leland A.
core +1 more source
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source
A quantum chemistry study of the dissociation and isomerization reactions of methylene amidogene
Journal of Molecular Structure: THEOCHEM, 2007 Abstract Quantum chemistry calculations at the MP2 and MRCI levels have been used to compute the energies of the stationary points and the minimum energy pathways (MEPs) between them for the dissociation and isomerization reactions of the methylene amido-gene radical. The MEPs for H2CN → trans-HCNH → cis-HCNH, H2CN → H + HCN, cis-HCNH → H + {HCN, HNC}
Metropoulos, Aristophanes +1 more
openaire +2 more sources