Results 111 to 120 of about 1,566,044 (372)

Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength.

Journal of Medicinal Chemistry, 2016
The association and dissociation kinetics of ligands binding to proteins vary considerably, but the mechanisms behind this variability are poorly understood, limiting their utilization for drug discovery.
Elena Segala, D. Guo, R. Cheng, A. Bortolato, F. Deflorian, A. S. Doré, J. Errey, L. Heitman, A. IJzerman, F. Marshall, R. Cooke   +10 more
semanticscholar   +1 more source

Experimental Determination of pKa Values by Use of NMR Chemical Shifts, Revisited [PDF]

, 2012
This laboratory experiment, using proton NMR spectroscopy to determine the dissociation constant for heterocyclic bases, has been modified from a previously described experiment. A solution of a substituted pyridine is prepared using deuterium oxide (D2O)
Gift, Alan D.
core   +1 more source

Polycyclic aromatic hydrocarbons and molecular hydrogen in oxygen-rich planetary nebulae: the case of NGC6720

, 2015
Evolved stars are primary sources for the formation of polycyclic aromatic hydrocarbons (PAHs) and dust grains. Their circumstellar chemistry is usually designated as either oxygen-rich or carbon-rich, although dual-dust chemistry objects, whose infrared
Berne, O., Cernicharo, J., Cox, N. L. J., Joblin, C., Pilleri, P.   +4 more
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A quimiometria nos cursos de graduação em química: proposta do uso da análise multivariada na determinação de pkª

Química Nova, 2014
An experiment was proposed applying the Chemometric approach of Multivariate Analysis for inclusion in undergraduate Chemistry courses to promote and expand the use of this analytical-statistical tool. The experiment entails the determination of the acid
Paulo Cesar de Souza Pereira, Camila Fabiano de Freitas, Cristiane Santi Chaves, Bianca Martins Estevão, Diogo Silva Pellosi, André Luiz Tessaro, Vagner Roberto Batistela, Ieda Spacino Scarminio, Wilker Caetano, Noboru Hioka   +9 more
doaj   +1 more source

Champagne Flutes and Brandy Snifters: Modelling Protostellar Outflow-Cloud Chemical Interfaces

, 2014
A rich variety of molecular species has now been observed towards hot cores in star forming regions and in the interstellar medium. An increasing body of evidence from millimetre interferometers suggests that many of these form at the interfaces between ...
Rawlings, Jonathan M. C., Redman, Matt P., Rollins, Richard P., Williams, David A.   +3 more
core   +1 more source

Isomerization as a Key Path to Molecular Products in the Gas-Phase Decomposition of Halons [PDF]

, 2010
The decomposition of halons remains controversial concerning the branching between radical and molecular products. The latter channel, where it has been found, is presumed to occur via a constrained symmetric multicenter transition state.
George, Lisa, Kalume, Aimable, Reid, Scott   +2 more
core   +2 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

In-depth sphingomyelin characterization using electron impact excitation of ions from organics and mass spectrometry[S]

Journal of Lipid Research, 2016
Electron impact excitation of ions from organics (EIEIO), also referred to as electron-induced dissociation, was applied to singly charged SM molecular species in the gas phase.
Takashi Baba, J. Larry Campbell, J. C. Yves Le Blanc, Paul R.S. Baker   +3 more
doaj  

Autocatalytic and cooperatively-stabilized dissociation of water on a stepped platinum surface [PDF]

, 2012
Water-metal interfaces are ubiquitous and play a key role in many chemical processes, from catalysis to corrosion. Whereas water adlayers on atomically flat transition metal surfaces have been investigated in depth, little is known about the chemistry of water on stepped surfaces, commonly occurring in realistic situations.
arxiv   +1 more source