Results 111 to 120 of about 1,352,916 (332)

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

open access: yesAdvanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso   +5 more
wiley   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

open access: yesAdvanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams   +7 more
wiley   +1 more source

Hydrogel‐Based Capacitive Sensor Model for Ammonium Monitoring in Aquaculture

open access: yesAdvanced Engineering Materials, EarlyView.
Traditional techniques for monitoring aquaculture water quality, particularly ammonium levels, harm fish. This work presents a novel capacitive sensor with an ionic hydrogel transducer to monitor ammonium concentration in real time based on the ammonium‐induced hydrogel dissociation and osmotic pressure. Monitoring aquaculture water quality, especially
Mohammad Mirzaee   +3 more
wiley   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

open access: yesAdvanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

On the Deformation Behavior of Metastable CrMnNi Steels Processed by Directed Energy Deposition in Different Temperature Regimes

open access: yesAdvanced Engineering Materials, EarlyView.
In the present study, metastable CrMnNi steels with varying chemical compositions and a concomitantly altered stacking fault energy are processed via directed energy deposition and afterwards tested via tensile tests at different temperatures. The present study shows the influence of the manufacturing process on the elemental deformation mechanisms for
Julia Richter   +8 more
wiley   +1 more source

Ag Cluster‐Modified K0.5Na0.5NbO3 Piezocatalyst for Enhanced Electrochemical Dinitrogen Reduction Reaction

open access: yesAdvanced Engineering Materials, EarlyView.
Ag cluster‐modified K0.5Na0.5NbO3 acts as an efficient piezocatalyst for electrochemical N2 reduction, enhanced by built‐in electric fields under mechanical actuation. Comparative studies between static and actuated electrodes reveal improved performance under dynamic conditions.
Benedict Witulski   +7 more
wiley   +1 more source

Key Trends and Insights in Smart Polymeric Skin Wearable Patches

open access: yesAdvanced Engineering Materials, EarlyView.
Intelligent polymers, which respond to various physical and biological stimuli, are explored for the development of skin wearable patches in biomedical applications. Smart polymers, also known as intelligent or stimuli‐responsive polymers, play a crucial role in the development of advanced wearable patches due to their versatility and softness.
Sergio J. Peñas‐Núñez   +2 more
wiley   +1 more source

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