Results 81 to 90 of about 13,758 (245)

Density Functional Theory Investigations on the Mechanism of Formation of Pa(V) Ion in Hydrous Solutions

Molecules, 2019
Due to the enormous threat of protactinium to the environment and human health, its disposal and chemistry have long been important topics in nuclear science.
Jun Ma, Chuting Yang, Jun Han, Jie Yu, Sheng Hu, Haizhu Yu, Xinggui Long   +6 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

De Svante Arrhenius ao peagâmetro digital: 100 anos de medida de acidez From Svante Arrhenius to the digital ph meter: a century of acidity measurement

Química Nova, 2007
This work describes the establishment of the concept of pH and the evolution of its measurement. The origin of the pH definition can be found in the development of the chemistry of aqueous solutions during the XIXth century. The electrolytic dissociation
Michelle da Silva Gama, Júlio Carlos Afonso   +1 more
doaj   +1 more source

Energy-dependent timescales in the dissociation of diiodothiophene dication

, 2023
Photodissociation molecular dynamics of gas-phase 2,5-diiodothiophene molecules was studied in an electron-energy-resolved electron-multi-ion coincidence experiment performed at the FinEstBeAMS beamline of MAX IV synchrotron.
Pihlava, L., Maclot, Sylvain,, Kooser, Kuno,, Strahlman, C., Pihlava, Lassi,, Kukk, E., Stråhlman, Christian,, Kukk, Edwin, Stråhlman, Christian, MacLot, Sylvain, Kooser, Kuno, Kivimäki, Antti, Kivimaki, A., Lund University., Kukk, Edwin,, Kivimäki, Antti,, Pihlava, Lassi, Kooser, K.   +17 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Sensing Microorganisms Using Rapid Detection Methods: Supramolecular Approaches

Biosensors
Supramolecular chemistry relies on the dynamic association/dissociation of molecules through non-covalent interactions. These interactions of a self-assembled system can be strategically exploited for sensing several microorganisms.
Hiya Lahiri, Kingshuk Basu
doaj   +1 more source

The polymerisation of oligo(ethylene glycol methyl ether) methacrylate from a multifunctional poly(ethylene imine) derived amide: a stabiliser for the synthesis and dispersion of magnetite nanoparticles [PDF]

, 2014
A facile synthetic route to poly(ethylene imine)-graft-poly(oligo(ethylene glycol methyl ether)) (PEI-graft-POEGMA) functionalised superparamagnetic magnetite nanoparticles is described.
Holder, SJ, Altan, Cem L., Bucak, Seyda, Yarar, U. Ecem, Holder, Simon J., Holder, S.J., Sommerdijk, Nico AJM Nico, Altan, C.L., Yarar, U.E., Kleine, A, Yarar, UE, Bucak, S, Sommerdijk, N.A.J.M., Bucak, S., Kleine, Aaron, Kleine, A., Sommerdijk, Nico A. J. M., Altan, CL Cem   +17 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Galaxy QCxMS for straightforward semi-empirical quantum mechanical EI-MS prediction

GigaByte
High-performance computing (HPC) environments are crucial for computational research, including quantum chemistry (QC), but pose challenges for non-expert users.
Wudmir Y. Rojas , Zargham Ahmad , Julia Jakiela , Helge Hecht , Jana Klánová , Elliott J. Price   +5 more
doaj   +1 more source

The thermodynamic chemistry of the aqueous copper-ammonia thiosulfate system

, 2006
A fundamental thermodynamic study was undertaken in order to establish the speciation of copper(I) and copper(II) during the leaching and recovery of gold from thiosulfate-copper-ammonia solutions. Despite considerable research into this complex leaching
Black, Silvia Beatriz
core