Results 51 to 60 of about 173,517 (257)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Bayesian analysis of high-throughput quantitative measurement of protein-DNA interactions.
PLoS ONE, 2011 Transcriptional regulation depends upon the binding of transcription factor (TF) proteins to DNA in a sequence-dependent manner. Although many experimental methods address the interaction between DNA and proteins, they generally do not comprehensively ...
David D Pollock +5 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Carrier-envelope-phase-dependent dissociation of hydrogen
New Journal of Physics, 2013 We studied the dependence of dissociative ionization in H _2 on carrier-envelope phase (CEP) of few-cycle (6 fs) near-infrared laser pulses. For low-energy channels, we present the first experimental observation of the CEP dependence of combined ...
Han Xu +6 more
doaj +1 more source
DETERMINATION OF THE SOLUBILITY OF SILVER NITRITE AND ITS DEGREE OF DISSOCIATION IN A SATURATED SOLUTION. [PDF]
Journal of the American Chemical Society, 1915 n ...
Creighton, Henry Jermain Maude +1 more
openaire +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Os diplomados do ensino superior : diferenciação sexual nos processos de inserção profissional [PDF]
Sociologia: Revista da Faculdade de Letras da Universidade do Porto, 2004 Based on the research carried out on the professional integration processes of university degree holders, the article intends to clarify their different configuration given the degree holder gender.
Mariana Gaio Alves
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Metalurgija, 2020 A procedure was developed to calculate the position of lines of monovariant phase equilibria for crystallization areas of congruently melting compounds through the dissociation degree of a chemical compound.The relevant mathematical apparatus was ...
S. Baisanov +4 more
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