Results 71 to 80 of about 3,021,829 (254)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Large Rapidity Gap Method to Select Soft Diffraction Dissociation at the LHC
Advances in High Energy Physics, 2016 In proton-proton (pp) collisions, any process involves exchanging the vacuum quantum numbers is known as diffractive process. A diffractive process with no large Q2 is called soft diffractive process.
Emily Nurse, Sercan Sen
doaj +1 more source
Quasinormal modes for quarkonium in a plasma with magnetic fields
Physics Letters B, 2019 Heavy vector mesons detected after a heavy ion collision are important sources of information about the quark gluon plasma. The fraction of such particles that survive the plasma phase and reach the detectors is related to the dissociation degree inside ...
Nelson R.F. Braga, Luiz F. Ferreira
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Kuangchan zonghe liyongThis is an article in the field of process mineralogy. Lithium is an important rare metal, which is widely used in metallurgy, machinery, chemical industry, ceramics, glass building materials and other industries, and becomes an important part of new ...
Yanqing CHEN +3 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The state scale of dissociation : development, psychometric validation, and application in a study of concurrent electro-encephalographic correlates [PDF]
The distinction between state and trait dissociation informed the development and psychometric validation of the State Scale of Dissociation (SSD) and the study of concurrent electro-encephalographic (EEG) correlates of experimentally induced ...
Krüger, Christina
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
, 2016 Dissociation is an abstract materialist film that has migrated from 16mm film to the digital. It is made up of scratches, half-baked images and flicker.
D de Bruyn (13734559)
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