Results 71 to 80 of about 177,329 (291)

女子大学生における否定的出来事の経験に関する記憶表象 : 解離性傾向との関連

, 2016
application/pdfAA11325308-20160220-18The present study examined the relationships among dissociation experience, adult children tendency, the memory representations of the most negative life event, and the psychological impact of the event.
MOROI, Katsuhide, ヤマモト, マオ, 諸井, 克英, ダイトウ, ナオ, IMAI, Yuki, 19, 80182286, 大東, 奈央, 山本, 真央, YAMAMOTO, Mao, DAITO, Nao, 1844, イマイ, ユキ, モロイ, カツヒデ, 1850, 1000080182286, 今井, 友紀, 1849, 1848, 1847, 1846, 1845   +21 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Os diplomados do ensino superior : diferenciação sexual nos processos de inserção profissional [PDF]

Sociologia: Revista da Faculdade de Letras da Universidade do Porto, 2004
Based on the research carried out on the professional integration processes of university degree holders, the article intends to clarify their different configuration given the degree holder gender.
Mariana Gaio Alves
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Numerical Study on Stratum Deformation during Dissociation Process of Methane Hydrate by Depressurization

Journal of MMIJ, 2017
Depressurization process is regarded as the most effective process for gas recovery method from the viewpoints of gas productivity and economic efficiency among in-situ dissociation processes of Methane Hydrate (MH) existing in marine sediments. However,
Masayo KAKUMOTO, Yasuhide SAKAMOTO, Kuniyuki MIYAZAKI, Norio TENMA, Kazuo AOKI, Akira TAKIGUCHI, Toshimasa ISHIBASHI, Jiro MORI   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Multi-factor sensitivity analysis on the stability of submarine hydrate-bearing slope

China Geology, 2018
: There are many factors affecting the instability of the submarine hydrate-bearing slope (SHBS), and the interaction with hydrate is very complicated. In this paper, the mechanical mechanism of the static liquefaction and instability of submarine slope ...
Liang Kong, Zhen-fei Zhang, Qing-meng Yuan, Qian-yong Liang, Yao-hong Shi, Jin-qing Lin   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

DETERMINATION OF THE SOLUBILITY OF SILVER NITRITE AND ITS DEGREE OF DISSOCIATION IN A SATURATED SOLUTION. [PDF]

Journal of the American Chemical Society, 1915
n ...
Creighton, Henry Jermain Maude, Ward, William Hillis   +1 more
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source