Results 81 to 90 of about 3,021,829 (254)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Stability Analysis of Methane Hydrate-Bearing Soils Considering Dissociation

Energies, 2015
It is well known that the methane hydrate dissociation process may lead to unstable behavior such as large ground deformations, uncontrollable gas production, etc. A linear instability analysis was performed in order to investigate which variables have a
Hiromasa Iwai, Sayuri Kimoto, Toshifumi Akaki, Fusao Oka   +3 more
doaj   +1 more source

Methane release from warming-induced hydrate dissociation in the West Svalbard continental margin: timing, rates, and geological controls

, 2013
Hundreds of plumes of methane bubbles, first observed in 2008, emanate from an area of the seabed off West Svalbard that has become 1°C warmer over the past 30 years. The distribution of the plumes, lying close to and upslope from the present upper limit
Thatcher, K.E., Westbrook, G.K., Sarkar, S., Minshull, T.A.   +3 more
core   +1 more source

Gas phase homolytic bond dissociation enthalpies of common laboratory solvents: A G4 theoretical study [PDF]

, 2010
Gas phase standard state (298.15 K, 1 atm) calculations were conducted at the Gaussian-4 (G4) composite method level of theory to estimate the bond dissociation enthalpies (BDEs) of various common laboratory solvents.
Sierra Rayne, Kaya Forest
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

POSSIBLE CAUSES OF DISSOCIATION BETWEEN PULMONARY EMBOLISM VOLUME AND RIGHT VENTRICULAR DYSFUNCTION DEGREE

Российский кардиологический журнал, 2012
Aim. To study possible causes of the dissociation between pulmonary embolism volume and right ventricular (RV) dysfunction degree. Material and methods.
Yu. B. Lishmanov, A. N. Pankova, K. V. Zavadovskyi   +2 more
doaj  

Investigation of the Structural State of a Liquid Mg–Zn Magnesium Alloy from the Perspective of the Behavior of the Bjerrum–Guggenheim Osmotic Coefficient in the Melt

Metals
Carrying out a series of fundamental studies in the field of physicochemical analysis, based on an approach that considers the phase state of alloys and accounts for the regular patterns of interaction of substances in multicomponent ores that are ...
Vera Tolokonnikova, Sailaubai Baisanov, Amankeldy Ahmetov, Yerbolat Makhambetov, Olzhas Kenzhaliyev, Alexey Orlov   +5 more
doaj   +1 more source

Effect of the Reactive Gas Activation Method on the Degree of Dissociation and Plasma Parameters of an ARC Discharge with a Hollow Cathode and Anode [PDF]

, 2022
The paper studies the influence of arc discharge parameters on the activation conditions of N2. The plasma spectrum and voltampere characteristics of a cylindrical probe are investigated.
Menshakov, A. I., Bryukhanova, Yu. A., Меньшаков, А. И., Брюханова, Ю. А.   +3 more
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source