Results 41 to 50 of about 59,210 (303)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Dissociative Amnesia beyond the Evidence about the Functioning of Memory [PDF]

, 2019
The reality of dissociative amnesia has been debated at length. From a clinical perspective, there is support for the existence of this phenomenon, with attempts to extrapolate it to legal contexts.
Manzanero Puebla, Antonio Lucas, Rubén Palomo, Antonio L. Manzanero, Palomo Seldas, Rubén   +3 more
core   +1 more source

Dysregulation in cortical reactivity to emotional faces in PTSD patients with high dissociation symptoms

European Journal of Psychotraumatology, 2013
Background: Predominant dissociation in posttraumatic stress disorder (PTSD) is characterized by restricted affective responses to positive stimuli. To date, no studies have examined neural responses to a range of emotional expressions in PTSD with high ...
Aleksandra Klimova, Richard A. Bryant, Leanne M. Williams, Kim Louise Felmingham   +3 more
doaj   +1 more source

Prevalence of Dissociative Convulsions in Patients with Dissociative Disorder in a Tertiary Care Hospital: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association, 2019
Introduction: Dissociative disorder is one of the common psychiatric problems encountered very frequently in the hospital setting. The aim of the study is to find out the prevalence of dissociative convulsions type in patients suffering from dissociative
Jai Bahadur Khattri, Bharat Kumar Goit, Rabindra Kumar Thakur   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Effectiveness of trauma-focused cognitive behavioral therapy on quality of trauma-related memory, dissociative experiences, and body image dissatisfaction in adolescents with complex post-traumatic stress disorder: A randomized controlled clinical trial

Journal of Education and Health Promotion
BACKGROUND: Repeated or prolonged experience of trauma can lead to complex post-traumatic stress disorder (CPTSD). This study aimed to determine the effectiveness of trauma-focused cognitive behavioral therapy (TF-CBT) on the quality of trauma-related ...
Homa Shahkaram, Maryam Bakhtiari, Alireza Ganjali, Amir Sam Kianimoghadam   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Relationship between Dissociative Experiences and Schizotypal Personality Traits: Mediating Role of Inferential Confusion

Iranian Journal of Psychiatry, 2021
Objective: Previous research has shown a relationship between schizotypal personality traits and dissociative tendencies. The Inference-Based Approach (IBA) can explain this relationship to some extent.
Akram Ghorbali, Mohammad Reza Shaeiri, Mohammad Gholami Fesharaki   +2 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Evaluation of Medetomidine Dose Variations on Tiletamine-Zolazepam and Tramadol Anesthetic Combination in Dogs

Animals
This study evaluated the effects of varying medetomidine doses on a tiletamine-zolazepam and tramadol anesthetic combination in dogs. The objective was to assess how medetomidine influences anesthesia depth, cardiovascular function, and recovery quality.
Donghwi Shin, Won-gyun Son, Jong-pil Seo, Min Jang, Inhyung Lee   +4 more
doaj   +1 more source