Results 71 to 80 of about 3,088 (284)

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis. [PDF]

, 2016
Molecular, genetic and pathological evidence suggests that deficits in GABAergic parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through alterations in the brain's excitation-inhibition balance that result in impaired ...
A Gokhale, A Kulak, A Monin, A Shiina, AR Mohn, AS Brown, AW Johnson, B Moghaddam, B Rodriguez-Santiago, BJ O'Roak, C Carmeli, C Ikonomidou, CS Weickert, D Ibi, D Jimenez-Blasco, D Martins-de-Souza, D Matsuzawa, DA Lewis, DC Javitt, DC Javitt, DJ Wyllie, DM Otte, DT Balu, DT Balu, ED Luby, EK Wirth, F Lante, G Kohr, G Lesca, GE Hardingham, GE Hardingham, GH Liu, Giles E. Hardingham, GL Carvill, GP Amminger, GZ Reus, H Morishita, H Pan, I Freunscht, J Dalmau, J Flatow, J Kantrowitz, J Lewerenz, J Tarabeux, JE Belforte, JH Cabungcal, JH Cabungcal, JH Cabungcal, JH Cabungcal, JH Krystal, JK Yao, JM Coughlin, JP Jacobsen, JR Lemke, JR Lemke, JT Coyle, JW Gawryluk, K Bodhinathan, K Gupta, K Hashimoto, KA Kennedy, KF Bell, KF Bell, KF Bell, KF Bell, KF Bell, Kim Q. Do, KQ Do, KQ Do, L Gan, LS Pilowsky, M Berk, M Buelna-Chontal, M Carlsson, M Farokhnia, M Guidi, MD Filiou, MI Mighdoll, MR Stefani, MY Yap, N Burnashev, NA Anis, NV Radonjic, O Howes, P Paoletti, P Steullet, P Steullet, PJ Uhlhaas, PS Baxter, R Beloosesky, R Dringen, R Gysin, R Morris, R Schwarcz, RA Myers, RE Kneeland, RF Deighton, RJ Fox, S Endele, S Fernandez-Fernandez, S Giovanoli, S Lavoie, S Papadia, S Schiavone, SA Back, SA Farr, SA Lipton, SB Powell, SD Greenhill, SK Natarajan, SW Group, T Hikida, T Korotkova, TR Insel, W Jin, X Wang, Y Goldsmit, Y Li, YB Choi, Z Jiang   +119 more
core   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs [PDF]

, 2014
Many important drugs approved to treat common human diseases were discovered by serendipity, without a firm understanding of their modes of action. As a result, the side effects and interactions of these medications are often unpredictable, and there is ...
Aamodt, Eric, Buttner, Edgar A., Cohen, Bruce, Dwyer, Donard S.   +3 more
core   +2 more sources

Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model

Advanced Healthcare Materials, EarlyView.
This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti, Cristina Richichi, Daniela Osti, Elena Ceccacci, Giovanni Bertalot, Camilla Cerutti, Giuseppina Giardina, Adriana Marinaro, Brunella Costanza, Valentina Gambino, Elena Zaccheroni, Daniela Tosoni, Maria G. Filippone, Marcello Del Corvo, Yinxiu Zhan, Teresa Gravina, Davide Corà, Monica Patanè, Bianca Pollo, Maria Giovanna Jodice, Salvatore Pece, Babette B. Weksler, Ignacio A. Romero, Pierre‐Olivier Couraud, Elisabetta Munzone, Massimiliano Del Bene, Francesco DiMeco, Giuliana Pelicci   +27 more
wiley   +1 more source

Exploring Novel Antidepressants Targeting G Protein-Coupled Receptors and Key Membrane Receptors Based on Molecular Structures

Molecules
Major Depressive Disorder (MDD) is a complex mental disorder that involves alterations in signal transmission across multiple scales and structural abnormalities.
Hanbo Yao, Xiaodong Wang, Jiaxin Chi, Haorong Chen, Yilin Liu, Jiayi Yang, Jiaqi Yu, Yongdui Ruan, Xufu Xiang, Jiang Pi, Jun-Fa Xu   +10 more
doaj   +1 more source

Depression during gestation in adolescent mothers interferes with neonatal neurobehavior [PDF]

, 2013
Objective: To compare the neurobehavior of neonates born to adolescent mothers with and without depression during gestation. Methods: This prospective cross-sectional study included healthy term neonates born to adolescent mothers with untreated ...
Barros, Marina Carvalho de Moraes, Chalem, Elisa, Guinsburg, Ruth, Laranjeira, Ronaldo, Mitsuhiro, Sandro Sendin   +4 more
core   +3 more sources

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Muscle-Type Nicotinic Receptor Blockade by Diethylamine, the Hydrophilic Moiety of Lidocaine [PDF]

, 2016
Lidocaine bears in its structure both an aromatic ring and a terminal amine, which can be protonated at physiological pH, linked by an amide group. Since lidocaine causes multiple inhibitory actions on nicotinic acetylcholine receptors (nAChRs), this ...
Alberola-Die, Armando, Fernández-Ballester, Gregorio, González-Ros, José M., Ivorra, Isabel, Morales, Andrés   +4 more
core   +4 more sources

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Characterization of Large Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction

, 2016
Several experiments evidence that specialized brain regions functionally interact and reveal that the brain processes and integrates information in a specific and structured manner. Networks can be used to model brain functional activities constituting a
Padovani, Eduardo C.
core