Results 81 to 90 of about 3,088 (284)

Acute pancreatitis in dogs and cats: medical imaging, biopsy, treatment and prognosis [PDF]

, 2010
Diagnosing acute pancreatitis in dogs and cats is difficult. Abdominal ultrasonography provides specific information about the size, shape and homogeneity of the pancreas, but is very dependent on the experience of the operator and the quality of the ...
Daminet, Sylvie, Hesta, Myriam, Paepe, Dominique, Saunders, Jimmy, Van den Bossche, I   +4 more
core   +1 more source

Safe and Localized Lentiviral Gene Delivery via Injectable Mesoporous Scaffolds for Potent Antitumor Immunity

Advanced Materials, EarlyView.
This work introduces an injectable mesoporous silica rod scaffold that confines lentiviral vectors to the injection site, enabling localized dendritic cell recruitment and transduction. The platform sustains antigen expression, promotes robust T‐cell activation, and enhances antitumor immunity.
Thanh Loc Nguyen, Yeon‐ju Kim, Jihye Im, Dong Kwang Min, Hyunsu Shin, Thuy An Trinh, Ngoc Man Phan, Min‐jeong Son, Ji‐yeon Shim, Ye‐lim Lee, Yujeong Ha, Kwang‐il Lim, Jaeyun Kim   +12 more
wiley   +1 more source

Epigenetic mechanisms of rapid-acting antidepressants

Translational Psychiatry
Background Rapid-acting antidepressants (RAADs), including dissociative anesthetics, psychedelics, and empathogens, elicit rapid and sustained therapeutic improvements in psychiatric disorders by purportedly modulating neuroplasticity, neurotransmission,
Antonio Inserra, Antonella Campanale, Tamim Rezai, Patrizia Romualdi, Tiziana Rubino   +4 more
doaj   +1 more source

Characterization of the Community Structure of Large Scale Functional Brain Networks During Ketamine-Medetomidine Anesthetic Induction

, 2016
One of the central questions in neuroscience is to understand the way communication is organized in the brain, trying to comprehend how cognitive capacities or physiological states of the organism are potentially related to brain activities involving ...
Padovani, Eduardo C.
core  

Anaesthetic effects of xylazine combinations in high and low concentrations of tiletamine-zolazepam, with and without ketamine, in cats [PDF]

, 2005
Intramuscular (1M) administration of four anaesthetic combinations were evaluated on nine cats ina repeated manner. The anaesthetic regimens were: (i) 2 mg/kg tiletamine, 2 mg/kg zolazepam, 3.2 mg/kg ketamine and 0.8 mg/kg xylazine (T₄KX); (ii) 1 mg/kg ...
Chee, S. K., Chen, Hui Cheng
core  

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, EarlyView.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Structure and Dynamics of Brain Lobes Functional Networks at the Onset of Anesthesia Induced Loss of Consciousness

, 2016
Anesthetic agents are neurotropic drugs able to induce dramatic alterations in the thalamo-cortical system, promoting a drastic reduction in awareness and level of consciousness.
Padovani, Eduardo C.
core  

Influence of local anesthetics and dissociative anesthetic ketamine on vocalization induced by electrical stimulation of sciatic nerve in rabbits

Japanese Journal of Oral Biology, 1981
The intravenous use of local anesthetics-particularly, lidocaine-as an analgesic, has interested anesthesiologists in recent years. They have reported the value of lidocaine as part of a mixed general anesthetic and as an analgesic for a postoperative pain. The dissociative anesthetic, ketamine, was reported to produce conspicuous analgesia. Therefore,
Takumi Sato, Kensuke Kisara, Kippei Goto, Yasumi Ogura   +3 more
openaire   +2 more sources

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source