Results 21 to 30 of about 215,287 (265)

Study of the Effect of Temperature on the Production of Carrageenan-Based Buccal Films and Optimization of the Process Parameters

Pharmaceuticals
Background/Objectives: Films in the mouth offer a promising alternative drug delivery system for oral administration, with several advantages over traditional oral formulations.
Katalin Kristó, Anahita Sangestani, Alharith A. A. Hassan, Hala Rayya, Krisztián Pamlényi, András Kelemen, Ildikó Csóka   +6 more
doaj   +1 more source

Crumbling Reefs and Cold-Water Coral Habitat Loss in a Future Ocean: Evidence of “Coralporosis” as an Indicator of Habitat Integrity

Frontiers in Marine Science, 2020
Ocean acidification is a threat to the net growth of tropical and deep-sea coral reefs, due to gradual changes in the balance between reef growth and loss processes. Here we go beyond identification of coral dissolution induced by ocean acidification and
Sebastian J. Hennige, Uwe Wolfram, Leslie Wickes, Leslie Wickes, Leslie Wickes, Fiona Murray, J. Murray Roberts, Nicholas A. Kamenos, Sebastian Schofield, Alexander Groetsch, Ewa M. Spiesz, Marie-Eve Aubin-Tam, Peter J. Etnoyer, Peter J. Etnoyer   +13 more
doaj   +1 more source

An In Vitro–In Vivo Comparison of Two Levodopa Dry Powder Products for Inhalation: A Randomized Trial Comparing Inbrija and Levodopa Cyclops

Pharmaceutics
Background/Objectives: The pulmonary administration of levodopa enables a rapid absorption and onset of action, making it a suitable administration route for managing OFF episodes in Parkinson’s disease.
Julia M. E. Berends, Ettina J. Wimmenhove, Marcel Hoppentocht, Paul Hagedoorn, Henderik W. Frijlink, Floris Grasmeijer   +5 more
doaj   +1 more source

Supramolecular Strategy Effects on Chitosan Bead Stability in Acidic Media: A Comparative Study

Gels, 2019
Chitosan beads attract interest in diverse applications, including drug delivery, biocatalysis and water treatment. They can be formed through several supramolecular pathways, ranging from phase inversion in alkaline solutions, to the ionic crosslinking ...
Andrew J. Worthen, Kelly S. Irving, Yakov Lapitsky   +2 more
doaj   +1 more source

Heat affected zone in surfacing chromium ledeburitic steel [PDF]

Metalurgija, 2010
Tools get failured during work; wear is a major factor that contributes to failures. Damaged tools are replaced or filed. This paper describes typical changes that occur in the heat affected zone of tool (HAZ), which was repaired by surfacing with a TIG ...
M. Tonkovič Prijanovič, L. Kosec
doaj  

Comparative Application of PLS and PCR Methods to Simultaneous Quantitative Estimation and Simultaneous Dissolution Test of Zidovudine - Lamivudine Tablets

Acta Chimica Slovenica, 2015
In the development strategies of new drug products and generic drug products, the simultaneous in-vitro dissolution behavior of oral dosage formulations is the most important indication for the quantitative estimation of efficiency and biopharmaceutical ...
Özgür Üstündağ, Erdal Dinç, Nurten Özdemir, Günseli M Tilkan   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Development and characterization of nanosuspensions of olmesartan medoxomil for bioavailability enhancement

Journal of Pharmacy and Bioallied Sciences, 2011
Background : Olmesartan medoxomil (OLM), an anti-hypertensive agent administered orally has absolute bioavailability of only 26% due to the poor aqueous solubility (
Hetal Paresh Thakkar, Bindesh Vishnubhai Patel, Sneha Piyush Thakkar   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source