Results 31 to 40 of about 494,411 (264)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Uv Spectrophotometric Method For Determination Of The Dissolution Profile Of Rivaroxaban
, 2014 Rivaroxaban is an oral anticoagulant that is the first available orally active direct Factor Xa inhibitor. In this study, a UV spectrophotometric method was developed for the determination of rivaroxaban content in pharmaceutical formulations and the ...
Celebier, Mustafa +3 more
core +1 more source
Journal of Pharmacy and Bioallied Sciences, 2011 Background : Olmesartan medoxomil (OLM), an anti-hypertensive agent administered orally has absolute bioavailability of only 26% due to the poor aqueous solubility (
Hetal Paresh Thakkar +2 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Indonesian Journal of Chemistry, 2020 In drug release kinetics, the drug-matrix interaction is one of the important mechanisms to be dictated. Unfortunately, there is still minimum information discussing the effect of interaction between a drug and its matrix to the release profile of the ...
Muhammad Al Rizqi Dharma Fauzi +3 more
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Comparison Of Dissolution Profiles Of Commercially Available Lamivudine Tablets
, 2015 The aim of this study was to investigate the influence of dissolution medium on the in vitro release of lamivudine (100 mg) from four commercially available lamivudine tablets (one reference and three generic). Three different buffer solutions (pH 1.2, 4.
Ozturk, Naile +2 more
core +1 more source
Dual-barrel conductance micropipet as a new approach to the study of ionic crystal dissolution kinetics [PDF]
, 2013 A new approach to the study of ionic crystal dissolution kinetics is described, based on the use of a dual-barrel theta conductance micropipet. The solution in the pipet is undersaturated with respect to the crystal of interest, and when the meniscus at ...
Massimo Peruffo +11 more
core +1 more source
Dissolution Method Troubleshooting: An Industry Perspective [PDF]
, 2022 Quality control dissolution testing represents a key product performance test for solid oral dosage forms and is the most likely QC test to result in laboratory investigations because of the relatively complex relationship between the dissolution ...
Scheubel, Emmanuel +12 more
core +1 more source
The impact of water flow rate on the dynamic dissolution kinetics of fractured limestone formations
Frontiers in Earth ScienceTo break through the lithological constraints on the surrounding rock for the construction of underground water-sealed oil storage caverns, and considering limestone as a potential host rock for such caverns, the dynamic evolution law of fracture ...
Dabao Xu +4 more
doaj +1 more source