Results 71 to 80 of about 371,966 (313)

Differential toxicity of bare and hybrid ZnO nanoparticles in green pea (Pisum sativum L.): A life cycle study

Frontiers in Plant Science, 2016
The effect of surface or lattice modification of nanoparticles (NPs) on terrestrial plants is poorly understood. We investigated the impact of different zinc oxide (ZnO) NPs on green pea (Pisum sativum L.), one of the highest consumed legumes globally ...
Dr. Arnab eMukherjee, Youping eSun, Erving eMorelius, Carlos eTamez, Susmita eBandyopadhyay, Genhua eNiu, Jason Christopher White, Jose R Peralta-Videa, Jorge L Gardea-Torresdey   +8 more
doaj   +1 more source

Development and Biopharmaceutical Evaluation of Tablets Based on the Poorly Water-soluble Substance 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil

Разработка и регистрация лекарственных средств, 2020
Introduction. 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil is a substance of scientific interest intended for the treatment of HIV-infection. However, its low bioavailability is a major limitation in successful drug delivery by oral route. Therefore, the
D. V. Demchenko, E. A. Jain (Korsakova), V. Yu. Balabanyan, M. N. Makarova, V. G. Makarov   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Intrinsic Dissolution as a Tool for Evaluating Drug Solubility in Accordance with the Biopharmaceutics Classification System

, 2011
The Biopharmaceutics Classification System (BCS) is a tool that was created to categorize drugs into different groups according to their solubility and permeability characteristics.
ISSA, Michele G., FERRAZ, Humberto G.
core  

Diffusion-controlled dissolution of a binary solid into a ternary liquid with partially molten zone formation [PDF]

, 2008
We build a theoretical model of equilibrium dissolution of a homogeneous, solid mixture of two salts A and B, KCl and NaCl being used as the type example, into an aqueous solution of the two salts, with diffusive transport.
Hatton, D. C., Woods, AW, Hatton, DC, Woods, A. W.   +3 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Effect of glycerin on indomethacin release profile from their liquisolid compacts

Journal of Mazandaran University of Medical Sciences, 2009
(Received 28 Sep, 2008 ; Accepted 6 May, 2009)AbstractBackground and purpose: The increasing effect of liquisolid systems on dissolution behavior of poor soluble drugs has been proved.
Majid Saeedi, Jafar Akbari, Reza Enayatifard, Shirin Sarreshtehdar   +3 more
doaj  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Evaluation Of Pharmaceutical Quality Of Conventional Dosage Forms Containing Paracetamol And Caffeine Available In The Turkish Drug Market

, 2016
The aim of this study was to evaluate the quality of conventional paracetamol- (PA) and caffeine- (CA) containing combined dosage forms in the Turkish drug market.
Akgeyik, Emrah, Celebier, Mustafa, Kaynak, Mustafa Sinan, Sahin, Selma, Altinoz, Sacide   +4 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source