Results 81 to 90 of about 446,173 (311)

In Vitro Dissolution Studies of Immediate Release and Extended Release Formulation using Flow-through Cell Apparatus 4. Dissolution technologies [PDF]

, 2014
The aims of this study were to evaluate the dissolution performance of solid dosage forms using the open and closed modes of the FTC Apparatus 4 under different flow rates and provide examples to demonstrate the advantages of the FTC method, in ...
Qiu, S., Wang, Ke, Li, M.
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effect of glycerin on indomethacin release profile from their liquisolid compacts

Journal of Mazandaran University of Medical Sciences, 2009
(Received 28 Sep, 2008 ; Accepted 6 May, 2009)AbstractBackground and purpose: The increasing effect of liquisolid systems on dissolution behavior of poor soluble drugs has been proved.
Majid Saeedi, Jafar Akbari, Reza Enayatifard, Shirin Sarreshtehdar   +3 more
doaj  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A review of the antecedents of union dissolution [PDF]

The question of what factors contribute to the stability of coresidential partnerships has attracted the attention of many social scientists. This study summarizes recent research on the determinants of union dissolution within a set of substantive ...
Torkild Lyngstad, Marika Jalovaara
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Dissolution Profile Evaluation of Eight Brands of Metformin Hydrochloride Tablets Available in Jimma, Southwest Ethiopia

Diabetes, Metabolic Syndrome and Obesity, 2021
Belachew Umeta,1 Anbessa Bekele,1 Tesfaye Mohammed,1,2 Markos Duguma,2 Henok Teshome,2 Yimer Mekonnen1,2 1Department of Pharmaceutical Sciences, School of Pharmacy, Institute of Health, Jimma University, Jimma, Oromia, Ethiopia; 2Jimma University ...
Umeta B, Bekele A, Mohammed T, Duguma M, Teshome H, Mekonnen Y   +5 more
doaj  

Electrocatalysis of Oxygen Reduction Reaction on Shape-Controlled Pt and Pd Nanoparticles—Importance of Surface Cleanliness and Reconstruction

Frontiers in Chemistry, 2019
Shape-controlled precious metal nanoparticles have attracted significant research interest in the recent past due to their fundamental and scientific importance.
Ruttala Devivaraprasad, Naresh Nalajala, Bapi Bera, Manoj Neergat   +3 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Solubility investigation of ketone and phenol essential oils in water using spectrometry and GC/MS [PDF]

Research Journal of Pharmacognosy, 2017
Background and objectives: Essential oils are used for their flavors and fragrances and their medicinal properties in food, cosmetic, agriculture and pharmaceutical industries.
doaj