Results 81 to 90 of about 944,725 (293)
Разработка и регистрация лекарственных средств, 2020 Introduction. 1-[2-(2-benzoylphenoxy)ethyl]-6-methyluracil is a substance of scientific interest intended for the treatment of HIV-infection. However, its low bioavailability is a major limitation in successful drug delivery by oral route. Therefore, the
D. V. Demchenko +4 more
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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
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Self unbound: ego dissolution in psychedelic experience [PDF]
, 2017 Users of psychedelic drugs often report that their sense of being a self or ‘I’ distinct from the rest of the world has diminished or altogether dissolved.
Gerrans, Philip, Letheby, Chris
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Effect of glycerin on indomethacin release profile from their liquisolid compacts
Journal of Mazandaran University of Medical Sciences, 2009 (Received 28 Sep, 2008 ; Accepted 6 May, 2009)AbstractBackground and purpose: The increasing effect of liquisolid systems on dissolution behavior of poor soluble drugs has been proved.
Majid Saeedi +3 more
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Local and global electrochemical impedances applied to the corrosion behaviour of an AZ91 magnesium alloy [PDF]
, 2009 The electrochemical behaviour of an AZ91 magnesium alloy was investigated in a low aggressive medium by means of local and global electrochemical impedance measurements. The results were compared to those obtained on a pure magnesium sample.
Galicia, Gonzalo +3 more
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FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Road and bridge construction across gypsum karst in England [PDF]
, 2002 Gypsum karst problems in the Permian and Triassic sequences of England have caused difficult conditions for bridge and road construction. In Northern England, the Ripon Bypass crosses Permian strata affected by active gypsum karst and severe subsidence ...
Anthony H Cooper +20 more
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FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Diabetes, Metabolic Syndrome and Obesity, 2021 Belachew Umeta,1 Anbessa Bekele,1 Tesfaye Mohammed,1,2 Markos Duguma,2 Henok Teshome,2 Yimer Mekonnen1,2 1Department of Pharmaceutical Sciences, School of Pharmacy, Institute of Health, Jimma University, Jimma, Oromia, Ethiopia; 2Jimma University ...
Umeta B +5 more
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