Results 61 to 70 of about 494,411 (264)
Journal of Advanced Pharmaceutical Technology & Research, 2013 The objective of the study was to prepare semisolid capsules (SSCs) of poorly water-soluble drug amlodipine besilate (AB) using a combination of technologies involving solid dispersion (SD) preparation and converting it into semisolid matrix filled in ...
Vijay K Tyagi +2 more
doaj +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
, 2009 Polymorphism and other solid-state phenomena can have effects on many physicochemical properties of pharmaceuticals. In this commentary, some aspects of solid-state pharmaceutics that are important to dissolution testing are highlighted.
Aaltonen, Jaakko +3 more
core +1 more source
Molecules, 2019 A multidrug crystal based on drug combinations was synthesized by the solvent evaporation method. This multicomponent crystal consisted of antidiabetic drugs Glimepiride (Gli) and Metformin (Met), which was performed by single crystal X-ray structure ...
Xufei Bian +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Statistical Properties of the Dissolution Test of USP [PDF]
, 2004 The dissolution test as defined in the United States Phar-macopoeia (1) is used in judging the quality of pharma-ceutical products. Dissolution testing is a method for evaluating physiological availability that depends upon having the drug in a dissolved
Carlos D. Saccone +3 more
core
A brief review of the FDA dissolution methods database
, 2020 The FDA Dissolution Database was reviewed using the following criteria: dosage forms, apparatus, rotation/pulsation speed, dissolution media, sampling time points, and trends for special dosage forms.
Shohin I.E. +4 more
core +2 more sources
Mineral dissolution in silicate melts [PDF]
, 2015 Quartz and orthopyroxene in mafic rocks are commonly observed to be surrounded by fringes of granular pyroxene, and of olivine and clinopyroxene, respectively. This study reproduces the conditions of formation of these textures, and investigates their
Curry, Richard M.
core +2 more sources
Frontiers in Plant Science, 2016 The effect of surface or lattice modification of nanoparticles (NPs) on terrestrial plants is poorly understood. We investigated the impact of different zinc oxide (ZnO) NPs on green pea (Pisum sativum L.), one of the highest consumed legumes globally ...
Dr. Arnab eMukherjee +8 more
doaj +1 more source