Results 1 to 10 of about 69,821 (158)
Alternative Methods for Dissolution Profile Comparison in the Dissolution Test
Разработка и регистрация лекарственных средств, 2021 Introduction. The article discusses the problem of assessing the similarity of the dissolution profiles of two batches of the nebivolol. The use of a generally accepted similarity factor for assessing equivalence is unacceptable in some cases, for ...
D. P. Romodanovsky, D. V. Goryachev
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Effect of xanthan gum-based food thickeners on the dissolution profile of fluoroquinolones oral formulations [PDF]
Journal of Pharmaceutical Health Care and Sciences, 2020 Background Xanthan gum-based food thickeners (XG-FTs) are often ingested by patients with dysphagia to prevent aspiration during drug treatment.
Nobuyuki Takahashi +4 more
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Dissolution Profile Evaluation of Eight Brands of Metformin Hydrochloride Tablets Available in Jimma, Southwest Ethiopia [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2021 Belachew Umeta,1 Anbessa Bekele,1 Tesfaye Mohammed,1,2 Markos Duguma,2 Henok Teshome,2 Yimer Mekonnen1,2 1Department of Pharmaceutical Sciences, School of Pharmacy, Institute of Health, Jimma University, Jimma, Oromia, Ethiopia; 2Jimma University ...
Umeta B +5 more
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Saquinavir-Piperine Eutectic Mixture: Preparation, Characterization, and Dissolution Profile [PDF]
Pharmaceutics, 2023 The dissolution rate of the anti-HIV drug saquinavir base (SQV), a poorly water-soluble and extremely low absolute bioavailability drug, was improved through a eutectic mixture formation approach. A screening based on a liquid-assisted grinding technique
Cinira Fandaruff +5 more
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Solubility and Dissolution Profile Assessment in Drug Discovery
Drug Metabolism and Pharmacokinetics, 2007 The purposes of the review are to: a) Provide a comprehensible introduction of the-state-of-the-art sciences of solubility and dissolution, b) introduce typical technologies to assess solubility and dissolution, and c) propose the best practice strategy. The theories of solubility and dissolution required in drug discovery were reviewed especially from
Kiyohiko Sugano
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Development and validation of a dissolution test for empagliflozin in film-coated tablets
Drug Analytical Research, 2021 The present study proposes a validated dissolution method for empagliflozin (EMPA) in film coated tablets. A gradual in vitro dissolution profile for this formulation was obtained using 900 mL of hydrochloric acid 0.01 M at 37 °C ± 0.5 °C as dissolution
Joanna Wittckind Manoel +3 more
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Preliminary assessment of influence of calcium alginate beads on the dissolution of meloxicam [PDF]
Acta Poloniae Pharmaceutica, 2023 The purpose of the study was to evaluate the preparation of alginate-based microparticles with meloxicam (MLX). A poorly soluble substance classified to BCS class II, it was chosen as a model substance.
Barbara Jadach +2 more
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Molecules, 2022 Controlled release matrices have predictable drug release kinetics, provide drugs for an extended period of time, and reduce dosing frequency with improved patient compliance as compared with conventional tablet dosage forms. In the current research work,
Kamran Ahmad Khan +9 more
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Pharmaceutical Fronts, 2021 Microsponge, a novel drug delivery system, is designed to deliver a pharmaceutically active ingredient efficiently at the minimum dose. Microsponge plays an important role in enhancing drug stability, reducing side effects, and modifying drug release ...
Anil Raosaheb Pawar +4 more
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Регуляторные исследования и экспертиза лекарственных средств, 2023 Scientific relevance. Hypromellose phthalate is used in enteric coatings for oral medicinal products. The proportion of phthalate groups in the polymer is standardised because it has a significant effect on solubility.
S. V. Moiseev +4 more
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