Results 21 to 30 of about 1,965,906 (302)

Compressibility of tableting materials and properties of tablets with glyceryl behenate

Acta Pharmaceutica, 2015
The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehenate at various concentrations.
Mužíková Jitka, Muchová Sandra, Komersová Alena, Lochař Václav   +3 more
doaj   +1 more source

Development and Characterization of a Novel Spray-Dried Powder for Inhalation of Cinacalcet HCl Nanoparticles [PDF]

Pharmaceutical Sciences
Background: Administering Cinacalcet HCl (CINA) can be challenging because of its low oral bioavailability (20 to 25%) due mainly to its high first-pass metabolism and poor aqueous solubility.
Katayoon Mireskandari, Mostafa Rostamnezhad, Majid Darabi, Mohammadreza Rouini, Alireza Vatanara   +4 more
doaj   +1 more source

Solubility Enhancement of Carvedilol by Solid Dispersion Technique Using Sodium Alginate, Guar Gum, Xanthan Gum, and Locust Bean Gum as Polymers

Indonesian Journal of Chemistry, 2023
Carvedilol (CVD) is a non-selective β-blocker. CVD is included in BCS class II. It has low water solubility. In this research, solid dispersion was used to increase the solubility and dissolution profile of CVD.
Iyan Sopyan, Nurdiani Adiningsih, Sandra Megantara, Siska Sari Marvita   +3 more
doaj   +1 more source

Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine) [PDF]

, 2007
Different liquisolid formulations of carbamazepine were accomplished by dissolving the drug in the non-toxic hydrophilic liquids, and adsorbing the solution onto the surface of silica.
Yousef Javadzadeh, Jafari-Navimipour, Baharak, Javadzadeh, Yousef, Yousef Javadzadeh (16203113), Baharak Jafari-Navimipour (16203116), Ali Nokhodchi, Baharak Jafari-Navimipour, Nokhodchi, Ali, Ali Nokhodchi (4465915)   +8 more
core   +1 more source

Dual-barrel conductance micropipet as a new approach to the study of ionic crystal dissolution kinetics [PDF]

, 2013
A new approach to the study of ionic crystal dissolution kinetics is described, based on the use of a dual-barrel theta conductance micropipet. The solution in the pipet is undersaturated with respect to the crystal of interest, and when the meniscus at ...
Massimo Peruffo, Kinnear, Sophie L., Kim McKelvey, McKelvey, Kim M. (Kim Martin), Unwin, Patrick R., Patrick R. Unwin, Peruffo, Massimo, Colburn, Alex W., Michael E. Snowden, Snowden, Michael E., Sophie L. Kinnear, Alex W. Colburn   +11 more
core   +1 more source

HIGH MOLECULAR CELLULOSE ESTERS. MECHANISM OF ACTION IN SUSTAINED RELEASE MATRIX TABLETS. DISSOLUTION PROFILE OF ACTIVE DRUG DEPENDING ON MOLECULAR WEIGHT AND HYDROPHILIC PROPERTIES OF POLYMERS

Фармация и фармакология (Пятигорск), 2015
This article reviews cellulose esters as important excipients in development of dosage forms with sustained release. We have studied modern methods of drug development, based on technological, and physical and chemical properties of excipients to provide
S. V. Trofimov
doaj   +1 more source

Assessment of Dissolution Profile of Marketed Aceclofenac Formulations [PDF]

Journal of Young Pharmacists, 2010
Statistical comparison of dissolution profiles under a variety of conditions relating to formulation characteristics, lot-to-lot, and brand-to-brand variation attracts interest of pharmaceutical scientist. The objective of this work is to apply several profile comparison approaches to the dissolution data of five-marketed aceclofenac tablet ...
Soni, T, Chotai, N
openaire   +2 more sources

Preparation and characterization of quercetin-polyvinylpyrrolidone K-30 spray dried solid dispersion [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2020
Context: The use of quercetin as a potential active pharmaceutical ingredient is limited by low aqueous solubility leading to low bioavailability. A spray-dried solid dispersion technique is used to increase the solubility and dissolution profiles of ...
Febriyenti, Peki Indra, Erizal Zaini, Friardi Ismed, Henny Lucida   +4 more
doaj  

A Critical Overview of FDA and EMA Statistical Methods to Compare In Vitro Drug Dissolution Profiles of Pharmaceutical Products

Pharmaceutics, 2021
A drug dissolution profile is one of the most critical dosage form characteristics with immediate and controlled drug release. Comparing the dissolution profiles of different pharmaceutical products plays a key role before starting the bioequivalence or ...
Jan Muselík, Alena Komersová, Kateřina Kubová, Kevin Matzick, Barbora Skalická   +4 more
doaj   +1 more source

A MULTIVARIATE TEST FOR SIMILARITY OF TWO DISSOLUTION PROFILES [PDF]

Journal of Biopharmaceutical Statistics, 2005
A multivariate test of size a for assessing the similarity of two dissolution profiles is proposed. The inferential procedure is developed by using the approach for the common mean problem in a multivariate setup due to Halperin (1961). The performance of the proposed method is compared with Intersection Union Test as well as f2 criterion recommended ...
H, Saranadasa, K, Krishnamoorthy
openaire   +2 more sources