Results 61 to 70 of about 5,768,654 (309)

Comparison Of Dissolution Profiles Of Commercially Available Lamivudine Tablets

, 2015
The aim of this study was to investigate the influence of dissolution medium on the in vitro release of lamivudine (100 mg) from four commercially available lamivudine tablets (one reference and three generic). Three different buffer solutions (pH 1.2, 4.
Ozturk, Naile, Kaynak, Mustafa Sinan, Sahin, Selma   +2 more
core   +1 more source

Experimental determination of plagioclase dissolution rates as a function of its composition and pH at 22°C. [PDF]

, 2014
The steady-state, far-from-equilibrium dissolution rates of nine distinct plagioclases ranging in composition from An2 to An89 were measured in mixed flow reactors at 22 ± 2 C and pH from 2 to 11.
Gudbrandsson S., Wolff-Boenisch D., Gislason S. R. and Oelkers E. H.
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Dissolution of CaO in SiO₂-CaO-Al₂O₃ Slag in Si Production

Metals
This work investigates the dissolution of CaO into three different compositions of SiO2-CaO-Al2O3 slag similar to those found in industrial Si furnaces. It was found that CaO dissolution into the slag is fast.
Marit Buhaug Folstad, Kristian Etienne Einarsrud, Merete Tangstad   +2 more
doaj   +1 more source

Enhancement of ketoconazole dissolution rate by the liquisolid technique

Acta Pharmaceutica, 2018
The study was conducted to enhance the dissolution rate of ketoconazole (KCZ) (a poorly water-soluble drug) using the liquisolid technique. Microcrystalline cellulose, colloidal silica, PEG400 and polyvinyl pyrrolidone (PVP) were employed as a carrier ...
Molaei Mir-Ali, Osouli-Bostanabad Karim, Adibkia Khosro, Shokri Javad, Asnaashari Solmaz, Javadzadeh Yousef   +5 more
doaj   +1 more source

The dissolution study of a South African magnesium-based material from different sources using a pH-stat [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2011
One of the main steps in the wet flue gas desulphurization (WFGD) process is the dissolution of either magnesite or limestone. Evaluating the magnesite dissolution rate is vital for the design and efficient operation of wet FGD plants.
Limo Rutto Hilary, Enweremadu Christopher   +1 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Enhancement of the dissolution rate and bioavailability of fenofibrate by a melt-adsorption method using supercritical carbon dioxide

International Journal of Nanomedicine, 2012
Kwang-Ho Cha,1,3 Kyung-Jin Cho,3 Min-Soo Kim,4 Jeong-Soo Kim,3 Hee Jun Park,1,3 Junsung Park,1,3 Wonkyung Cho,1,3 Jeong-Sook Park,3 Sung-Joo Hwang1,21Yonsei Institute of Pharmaceutical Sciences, 2College of Pharmacy, Yonsei University, Incheon, Republic ...
Cha KH, Cho KJ, Kim MS, Kim JS, Park HJ, Park J, Cho W, Park JS, Hwang SJ   +8 more
doaj  

Preparation and characterization of simvastatin/DMβCD complex and its pharmacokinetics in rats

Acta Pharmaceutica, 2018
Simvastatin is poorly bioavailable because it is practically insoluble in water and shows dissolution rate-limited absorption. Solubilizing effects of several β-cyclodextrin (βCD) derivatives such as HPβCD, SBEβCD and DMβCD on simvastatin in aqueous ...
Gu Fugen, Ning Jia, Fan Huimin, Wu Chunzhi, Wang Yi   +4 more
doaj   +1 more source