Results 61 to 70 of about 5,482,491 (310)
Preparation and characterization of simvastatin/DMβCD complex and its pharmacokinetics in rats
Acta Pharmaceutica, 2018 Simvastatin is poorly bioavailable because it is practically insoluble in water and shows dissolution rate-limited absorption. Solubilizing effects of several β-cyclodextrin (βCD) derivatives such as HPβCD, SBEβCD and DMβCD on simvastatin in aqueous ...
Gu Fugen +4 more
doaj +1 more source
Applied Sciences, 2019 We present the anti-solvent precipitation of hydrophobic drugs griseofulvin (GF) and sulfamethoxazole (SMZ) in the presence of carboxylated carbon nanotubes (f-CNTs).
Kun Chen, Somenath Mitra
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2016 Objectives To understand the impact of ionic and non-ionic surfactants on the dissolution and stability properties of amorphous polymeric dispersions using griseofulvin (GF) as a model for poorly soluble drugs.
Al-Obaidi, Hisham +5 more
core +1 more source
Mineral dissolution in silicate melts [PDF]
, 2015 Quartz and orthopyroxene in mafic rocks are commonly observed to be surrounded by fringes of granular pyroxene, and of olivine and clinopyroxene, respectively. This study reproduces the conditions of formation of these textures, and investigates their
Curry, Richard M.
core +2 more sources
The Influence of Milling on the Dissolution Performance of Simvastatin
Pharmaceutics, 2010 Particle size reduction is a simple means to enhance the dissolution rate of poorly water soluble BCS-class II and IV drugs. However, the major drawback of this process is the possible introduction of process induced disorder.
Thomas Rades +5 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Science and Technology Indonesiap-methoxycinnamic acid (pMCA) has activity as an anti- inflammatory and analgesic but is difficult to dissolve in water with a solubility of only 0.712 mg/mL at 25 oC.
Abhimata Paramanandana +4 more
doaj +1 more source
Pharmaceutics, 2018 This study aimed to design phosphatidylcholine (PC)-based solid dispersion (SD) systems for enhancing the apparent aqueous solubility and dissolution of celecoxib (CLC), a selective cyclooxygenase-2 inhibitor with a highly hydrophobic property.
Kanghee Jo +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source