Results 81 to 90 of about 1,155,170 (317)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Rational Prediction of Distal Activity-Enhancing Mutations in Tryptophan Synthase

, 2021
Allostery is a central mechanism for the regulation of multi-enzyme complexes. The mechanistic basis that drives allosteric regulation is poorly understood, but harbors key information for enzyme engineering.
Reinhard, Sterner, Sílvia, Osuna, Javier, Iglesias-Fernández, Thomas, Kinateder, Miguel ÁNgel, Maria-Solano   +4 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Novel Lag Screw Application In The Reduction Of Neer Type V Distal Clavicle Fracture: A Case Report And Technical Note

Journal of Orthopaedic Case Reports
Introduction: Neer Type V distal clavicle fractures are an unstable fracture configuration that is often treated with surgery. Type V fractures are challenging as the integrity of the coracoclavicular ligament needs to be restored by reducing the ...
Shaun Kai Kiat Chua, Don Thong Siang Koh, Junkai Liow, Michael Gui Jie Yam   +3 more
doaj   +1 more source

Distal Mentoring: An Antidote to Toxicity? [PDF]

International Journal of Evidence Based Coaching and Mentoring, 2013
Failures in mentoring relationships threaten outcomes and can lead to chronic damage to participants. This paper reports on findings from a recent doctoral study to establish how a developmental mentoring model would impact toxicity.
Rhianon Washington
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Locking plates for distal femur fractures does an increased working length improve healing?

, 2013
Includes abstract.Includes bibliographical references.Distal femur locking plates have become a very popular means of internal fixation because of their ability to provide stable distal periarticular fixation.
Koller, Ian M
core  

Relative frequency dynamics and loading of beet necrotic yellow vein virus genomic RNAs during the acquisition by its vector Polymyxa betae

Journal of Virology
The beet necrotic yellow vein virus (BNYVV) is a multipartite virus with the highest number (up to five) of genomic segments among RNA viruses. Classified as a soil-borne virus, it is persistently transmitted by the protozoan Polymyxa betae.
Yi Guo, Mattia Dall'Ara, David Baldo, David Gilmer, Claudio Ratti   +4 more
doaj   +1 more source

Application of different analytical methods for the determination of phenols and antioxidant activity in hawthorn (Crataegus spp.) bud and sprout herbal extracts

Journal of Applied Botany and Food Quality, 2020
Hawthorn (Crataegus spp., family: Rosaceae) extracts have been used as pharmaceutical preparations owing to positive effects on cardiovascular system. The AlCl3-based official method employed for the determination of pharmacologically active compounds ...
Federico Ferioli, Elisa Giambanelli, L. Filippo D'Antuono   +2 more
doaj   +1 more source