Results 61 to 70 of about 1,243,090 (307)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Salt Tolerance and Na Allocation in Sorghum bicolor under Variable Soil and Water Salinity

open access: yesPlants, 2020
Salinity is a major constraint for plant growth in world areas exposed to salinization. Sorghum bicolor (L.) Moench is a species that has received attention for biomass production in saline areas thanks to drought and salinity tolerance.
Roberta Calone   +6 more
doaj   +1 more source

QTL mapping identifies novel major loci for kernel row number-associated ear fasciation, ear prolificacy and tillering in maize (Zea mays L.)

open access: yesFrontiers in Plant Science, 2023
Maize ear fasciation originates from excessive or abnormal proliferation of the ear meristem and usually manifests as flattened multiple-tipped ear and/or disordered kernel arrangement.
Kai Li   +6 more
doaj   +1 more source

Distal pancreatectomy for gunshot injuries of the distal pancreas

open access: yesJournal of British Surgery, 1995
Abstract This study comprised 57 patients with gunshot injury of the distal pancreas. There were 16 grade II, 29 grade III and 12 grade IV pancreatic injuries. The intraoperative mortality rate was 12 per cent. Patients with the most severe grade II injuries and all those with grade III and IV injuries had distal pancreatectomy and ...
E, Degiannis   +5 more
openaire   +4 more sources

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Beneficial metabolic transformations and prebiotic potential of hemp bran and its alcalase hydrolysate, after colonic fermentation in a gut model

open access: yesScientific Reports, 2023
Hemp seed bran (HB) is an industrial food byproduct that is generally discarded. Knowledge on the functional capabilities of HB is limited and it is not known the impact of HB on human colon microbiota, where vegetable fibers are metabolized.
Lorenzo Nissen   +3 more
doaj   +1 more source

Honeybee Exposure to Veterinary Drugs: How Is the Gut Microbiota Affected?

open access: yesMicrobiology Spectrum, 2021
Several studies have outlined that a balanced gut microbiota offers metabolic and protective functions supporting honeybee health and performance. The present work contributes to increasing knowledge on the impact on the honeybee gut microbiota of the ...
Loredana Baffoni   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Double-cropping autumn-sown camelina with food crops and pelargonic acid application

open access: yesIndustrial Crops and Products
Double-cropping systems represent a sustainable strategy to produce feedstock for the biobased industry without reducing food security, while simultaneously improving farmer profitability.
Maria Giovanna Sessa   +8 more
doaj   +1 more source

A Review of the Effect of Formic Acid and Its Salts on the Gastrointestinal Microbiota and Performance of Pigs

open access: yesAnimals, 2020
Out of the alternatives to antibiotics and zinc oxide, organic acids, or simply acidifiers, play significant roles, especially in ensuring gut health and the growth performance of pigs.
Diana Luise   +3 more
doaj   +1 more source

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