Results 101 to 110 of about 8,115,379 (305)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The use of WCAG and automatic tools by computer science students: a case study evaluating MOOC accessibility [PDF]

Journal of Universal Computer Science
Web Content Accessibility Guidelines (WCAG) have been the de facto standard for Web accessibility evaluation for more than two decades and therefore have been introduced into legislation and university curriculum in Computer Science.
Francisco Iniesto, Covadonga Rodrigo
doaj   +3 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Exploring career aspirations and development barriers of university accounting students: the explanatory sequential mixed methods perspectives

Discover Education
Career aspirations and career development are major concerns in national building. This study explored the career aspirations of final year B.Ed. Accounting students in a Ghanaian university and the barriers that prevented them from achieving their ...
Lydia Aframea Dankyi, Joyce Kwakyewaa Dankyi, Richlove Owusu-Achiaw, Moses Segbenya   +3 more
doaj   +1 more source

Authenticity of Ficus Hispida as a Local Traditional Product in the Lembah Lenggong World Heritage Site

SHS Web of Conferences, 2014
Lembah Lenggong is a place well known amongst locals as an archaeological site; the valley has been attested as a World Heritage Site. There is an overwhelming variety of plant species that are uniquely used in their cultural and traditional cuisines ...
Abd Aziz Siti Hajar, Zakaria Zuraini, Mohammad Ziyad Rafiqi   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The same course, different access: the digital divide between urban and rural distance education students in South Africa

Journal of Geography in Higher Education, 2019
Access to education is a significant determinant in future success, not only for a country but equally for individuals. Higher Education (HE) thus is an integral part of the Sustainable Development Goals and vital in supporting African development ...
R. Lembani, A. Gunter, M. Breines, M. Dalu   +3 more
semanticscholar   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Challenges Faced by Adult Learners in Online Distance Education: A Literature Review

Open Praxis, 2019
Although online distance education provides adult learners with an opportunity for life-long learning, there are still factors challenging them to engage in educational processes.
M. Kara, Fatih Erdoğdu, Mehmet Kokoç, Kursat Cagiltay   +3 more
semanticscholar   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source