Results 61 to 70 of about 1,047,569 (316)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Ultra-long-period Cepheids as Standard Candles from Gaia to Rubin-LSST
The Astrophysical Journal Supplement SeriesAn analysis of the properties of ultra-long-period Cepheids (ULPs) could significantly contribute to understanding the Hubble constant tension, e.g., the current discrepancy between determinations based on local distance indicators and those relying on ...
Ilaria Musella +12 more
doaj +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
On degree- and -distance-based topological indices
Revue Roumaine de Chimie, 2021 In addition to a great variety of degree-based and distance-based molecular structure descriptors, there are a few degree-and-distance-based topological indices. Two main such indices are the degree distance (DD) and the Gutman index (ZZ). Their mutual relations are analyzed and several new such relations established.
openaire +2 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Distance Indicators in the Magellanic Clouds [PDF]
Highlights of Astronomy, 1983 In talking about the overall distance scale of the Universe and the Hubble Constant, the Magellanic Clouds are good places to start. They are stellar systems large enough to contain stars, clusters and nebulae of all types, covering a wide age range. With modern telescopes and detectors, we are able to observe stars from the very bright down to those ...
openaire +2 more sources
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
Measurement of noise events in road traffic streams: initial results from a simulation study [PDF]
, 2016 A key question for road traffic noise management is whether prediction of human response to noise, including sleep quality, could be improved over the use of conventional energy equivalent, or percentile, measures, by accounting for noise events in road ...
Brown, Lex +2 more
core
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Young stellar distance indicators and the extragalactic distance scale
, 2023 Invited review at 2022 RR Lyrae and Cepheids conference on La Palma.
openaire +2 more sources