Results 71 to 80 of about 1,090,152 (292)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The TRGB-SBF Project. I. A Tip of the Red Giant Branch Distance to the Fornax Cluster with JWST

The Astrophysical Journal
Differences between the local value of the Hubble constant measured via the distance ladder versus the value inferred from the cosmic microwave background with the assumption of the standard ΛCDM model have reached over 5 σ significance.
Gagandeep S. Anand, R. Brent Tully, Yotam Cohen, Dmitry I. Makarov, Lidia N. Makarova, Joseph B. Jensen, John P. Blakeslee, Michele Cantiello, Ehsan Kourkchi, Gabriella Raimondo   +9 more
doaj   +1 more source

Distance Advanced Training of Preschool Teachers in Ukraine: Quantitative Indicators

Online Learning in Educational Research
The study highlights the stages of organizing distance learning advanced training courses. It is a quantitative analysis of preschool teachers who have completed advanced training courses under the «Education Care» educational program. For this research,
Tetiana Sharova, Volodymyr Voronov, Sergii Sharov, Halyna Kolomoiets, Anna Voronova   +4 more
doaj   +1 more source

Measurement of noise events in road traffic streams: initial results from a simulation study [PDF]

, 2016
A key question for road traffic noise management is whether prediction of human response to noise, including sleep quality, could be improved over the use of conventional energy equivalent, or percentile, measures, by accounting for noise events in road ...
Brown, Lex, De Coensel, Bert, McBroom, James   +2 more
core  

Photometric Solutions for Detached Eclipsing Binaries: selection of ideal distance indicators in the SMC

, 2001
Detached eclipsing binary stars provide a robust one-step distance determination to nearby galaxies. As a by-product of Galactic microlensing searches, catalogs of thousands of variable stars including eclipsing binaries have been produced by the OGLE ...
Barnes T. G., Di Benedetto G. P., Grison P., J. S. B. Wyithe, Kruszewski A., Levenberg K., Paczynski B., R. E. Wilson, Semeniuk I., Udalski A., Wilson R. E.   +10 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The TRGB-SBF Project. IV. A Color Calibration of the TRGB in the JWST F090W+F150W Filters

The Astrophysical Journal
Observations with JWST in the F090W band provide a powerful tool for determining galaxy distances based on tip of the red giant branch (TRGB) measurements. It is a great convenience that the TRGB lies at an almost constant absolute magnitude level at low
Maksim I. Chazov, Dmitry I. Makarov, R. Brent Tully, Gagandeep S. Anand, Lidia N. Makarova, Yotam Cohen, John P. Blakeslee, Michele Cantiello, Joseph B. Jensen, Gabriella Raimondo   +9 more
doaj   +1 more source

Novae as distance indicators [PDF]

Nova shells are characteristically prolate with equatorial bands and polar caps. Failure to account for the geometry can lead to large errors in expansion parallaxes for individual novae.
Ciardullo, Robin, Ford, Holland C.
core   +1 more source

On degree- and -distance-based topological indices

Revue Roumaine de Chimie, 2021
In addition to a great variety of degree-based and distance-based molecular structure descriptors, there are a few degree-and-distance-based topological indices. Two main such indices are the degree distance (DD) and the Gutman index (ZZ). Their mutual relations are analyzed and several new such relations established.
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source