Results 81 to 90 of about 7,395,903 (283)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Accelerating Stellar Photometric Distance Estimates with Neural Networks

The Astronomical Journal
Building on the Bayesian approach to estimating stellar distances from broadband photometry, we show that the computation can be accelerated by about an order of magnitude by using neural networks. Focusing on the case of the ugrizy filter complement for
Karlo Mrakovčić, Željko Ivezić, Lovro Palaversa   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

PhotoD with LSST: Stellar Photometric Distances Out to the Edge of the Galaxy

The Astronomical Journal
As demonstrated with the Sloan Digital Sky Survey (SDSS), Pan-STARRS, and most recently with Gaia data, broadband near-UV to near-IR stellar photometry can be used to estimate distance, metallicity, and interstellar dust extinction along the line of ...
Lovro Palaversa, Željko Ivezić, Neven Caplar, Karlo Mrakovčić, Bob Abel, Oleksandra Razim, Filip Matković, Connor Yablonski, Toni Šarić, Tomislav Jurkić, Sandro Campos, Melissa DeLucchi, Derek Jones, Konstantin Malanchev, Alex I. Malz, Sean McGuire, Mario Jurić   +16 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Distance Advanced Training of Preschool Teachers in Ukraine: Quantitative Indicators

Online Learning in Educational Research
The study highlights the stages of organizing distance learning advanced training courses. It is a quantitative analysis of preschool teachers who have completed advanced training courses under the «Education Care» educational program. For this research,
Tetiana Sharova, Volodymyr Voronov, Sergii Sharov, Halyna Kolomoiets, Anna Voronova   +4 more
doaj   +1 more source

Araucaria Project: Pulsating stars in binary systems and as distance indicators

EPJ Web of Conferences, 2017
Pulsating stars, like Cepheids or RR Lyrae stars, are ones of the most important distance indicators. They are also key objects for testing the predictions of stellar evolution and stellar pulsation theory.
Pilecki Bogumił, Gieren Wolfgang, Pietrzyński Grzegorz, Smolec Radosław   +3 more
doaj   +1 more source

Cepheids as Distance Indicators

, 1996
We review the use of Cepheids as distance indicators with particular emphasis on the methods which have been applied to HST observations of Cepheids. The calibration of the period-luminosity relations is examined in detail and we identify possible problems with the existing calibrations. New V- and I-band period luminosity relations are presented based
openaire   +2 more sources