Results 61 to 70 of about 4,837,596 (345)

Matrix versions of the Hellinger distance [PDF]

Letters in Mathematical Physics, 2019
On the space of positive definite matrices, we consider distance functions of the form $$d(A,B)=\left[ \mathrm{tr}\mathcal {A}(A,B)-\mathrm{tr}\mathcal {G}(A,B)\right] ^{1/2},$$d(A,B)=trA(A,B)-trG(A,B)1/2, where $$\mathcal {A}(A,B)$$A(A,B) is the ...
R. Bhatia, S. Gaubert, Tanvi Jain
semanticscholar   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

IMPLEMENTATION OF THE BRANCH AND BOUND METHOD FOR THE PROBLEM OF RECOVERING A DISTANCES MATRIX BETWEEN DNA STRINGS

Современные информационные технологии и IT-образование, 2019
Bioinformatics has two important problems for the study of evolutionary processes: calculating the distance between DNA sequences and restoring a matrix of distances sequences of different genomes when not all initial elements are known. Due to the large
Mikhail E. Abramyan, Boris F. Melnikov, Marina A. Trenina   +2 more
doaj   +1 more source

Factoring distance matrix polynomials

Discrete Mathematics, 1993
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Four-point condition matrices of edge-weighted trees

Special Matrices
Formulas for the determinant of distance matrix DT{D}_{T} of tree TT are known in the unweighted case and in the case when the edges of TT have commuting variable weights. Associated with the four-point condition (4PC) and a tree TT are two matrices, the
Azimi Ali, Jana Rakesh, Nagar Mukesh K., Sivasubramanian Sivaramakrishnan   +3 more
doaj   +1 more source

Research on decision method based on probability hesitation fuzzy comprehensive distance measure

Xibei Gongye Daxue Xuebao, 2023
Aiming at the defects of the existing probabilistic hesitation fuzzy distance measures, which require the number of membership degree to be consistent and the order to be rearranged, a probabilistic hesitation fuzzy multi-attribute decision making method
LIU Ying, GUAN Xin, WU Bin
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Clustering the objective interestingness measures based on tendency of variation in statistical implications

EAI Endorsed Transactions on Context-aware Systems and Applications, 2016
In recent years, the research cluster of objective interestingness measures has rapidly developed in order to assist users to choose the appropriate measure for their application.
Nghia Quoc Phan, Vinh Cong Phan, Hung Huu Huynh, Hiep Xuan Huynh   +3 more
doaj   +1 more source