Results 91 to 100 of about 4,918,184 (297)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Running head: PHONOLOGICAL DISTANCE MEASURES Phonological Distance Measures

, 2008
Phonological distance measures 2 Phonological distance can be measured computationally using formally specified algorithms. This work investigates two such measures, one developed by Nerbonne and Heeringa (1997) based on Levenshtein distance (Levenshtein,
Nathan C Sanders, Steven B Chin, Phonological Distance Measures   +2 more
core  

New distance measure for comparing protein using cellular automata image. [PDF]

PLoS One, 2023
F Souza L, B de B Pereira H, M da Rocha Filho T, A S Machado B, A Moret M.   +4 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Evolutionary Multi-Tasking Optimization for High-Efficiency Time Series Data Clustering

Tsinghua Science and Technology
Time series clustering is a challenging problem due to the large-volume, high-dimensional, and warping characteristics of time series data. Traditional clustering methods often use a single criterion or distance measure, which may not capture all the ...
Rui Wang, Wenhua Li, Kaili Shen, Tao Zhang, Xiangke Liao   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Distance, similarity and entropy measures of n-dimensional fuzzy sets

Mathematics in Applied Sciences and Engineering
An $n$-dimensional fuzzy set generalizes other fuzzy structures and effectively addresses real-world problems by providing greater flexibility in assigning membership values through the selection of an arbitrarily large $n$.
Jomal Josen, Sunil Jacob John, T. Baiju
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Cluster Validity Index for Uncertain Data Based on a Probabilistic Distance Measure in Feature Space. [PDF]

Sensors (Basel), 2023
Ko C, Baek J, Tavakkol B, Jeong YS.
europepmc   +1 more source