Results 81 to 90 of about 858,759 (313)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Optimization of Pinned Photodiode Pixels for High-Speed Time of Flight Applications

IEEE Journal of the Electron Devices Society, 2018
We discuss optimizations of pinned photodiode (PPD) pixels for indirect time of flight sensors. We focus on the transfer-gate and dumping gate regions optimization, on the PPD dimension and shape to assure fast lateral charge transfer and on the ...
Fabio Acerbi, Manuel Moreno-Garcia, Gozen Koklu, Radoslaw Marcin Gancarz, Bernhard Buttgen, Alice Biber, Daniel Furrer, David Stoppa   +7 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Novel logarithmic distance and similarity measures for hesitant fuzzy sets and their application in groundwater depletion analysis

Fuzzy Information and Engineering
Here, we propose logarithmic-based distance and similarity measures for Hesitant Fuzzy Sets (HFSs) as an extension of fuzzy set theory to better capture uncertainty in decision-making problems.
Rahul Thakur, Masum Raj, S.C. Malik
doaj   +1 more source

New distance measure for comparing protein using cellular automata image. [PDF]

PLoS One, 2023
F Souza L, B de B Pereira H, M da Rocha Filho T, A S Machado B, A Moret M.   +4 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Modelling a suspension for an experiment to measure the speed of gravity in short distances [PDF]

, 2021
W C S Ramalho, F S Bortoli, Nadja S. Magalhães, Raimundo Duarte, Carlos Frajuca, Renato Chaves Souza   +5 more
openalex   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Distance, similarity and entropy measures of n-dimensional fuzzy sets

Mathematics in Applied Sciences and Engineering
An $n$-dimensional fuzzy set generalizes other fuzzy structures and effectively addresses real-world problems by providing greater flexibility in assigning membership values through the selection of an arbitrarily large $n$.
Jomal Josen, Sunil Jacob John, T. Baiju
doaj   +1 more source

Sharp asymptotic and finite-sample rates of convergence of empirical measures in Wasserstein distance [PDF]

, 2019
Jonathan Weed, Francis Bach
openalex   +1 more source