Results 81 to 90 of about 3,905,406 (202)
Evolutionary Multi-Tasking Optimization for High-Efficiency Time Series Data Clustering
Tsinghua Science and TechnologyTime series clustering is a challenging problem due to the large-volume, high-dimensional, and warping characteristics of time series data. Traditional clustering methods often use a single criterion or distance measure, which may not capture all the ...
Rui Wang +4 more
doaj +1 more source
The Directional Profit Efficiency Measure: On Why Profit Inefficiency is either Technical or Allocative [PDF]
The directional distance function has been introduced in the efficiency literature with the intention of relaxing the fixed orientations represented by its classical input and output counterparts.
Zofío, José Luis +2 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Distance, similarity and entropy measures of n-dimensional fuzzy sets
Mathematics in Applied Sciences and EngineeringAn $n$-dimensional fuzzy set generalizes other fuzzy structures and effectively addresses real-world problems by providing greater flexibility in assigning membership values through the selection of an arbitrarily large $n$.
Jomal Josen, Sunil Jacob John, T. Baiju
doaj +1 more source
A Scale Elasticity Measure for Directional Distance Function and its Dual [PDF]
In this paper we introduce a scale elasticity measure based on directional distance function for multi-output-multi-input technologies and explore its fundamental properties.
Valentin Zelenyuk
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Exploring the use of distance education technology for lifestyle change
, 2011 Obesity affects over 100 million men, women, and children in North America alone and has reached what health professionals deem to be epidemic proportions.
Patrick J. Tierney
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source