Results 61 to 70 of about 3,905,406 (202)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Average Distance Measure for TOPSIS-Sine Trigonometric Single-valued Neutrosophic Weighted Aggregation Operator and Its Application in Decision Making [PDF]

Neutrosophic Sets and Systems
The aggressive work involved in proposing new distance measures between two neutrosophic sets has been obvious for the past ten years. These continuous efforts are commonly motivated by the need to provide a variety of alternatives in the study of ...
Roliza Md Yasin, Nurul Izzah Wardah Salim, Nik Fakhira Nik Ahmad Fuad, Noorzahirah Mohd Zahali, Suriana Alias, Norzieha Mustapha   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Cutting-Edge TOPSIS Approach for Navigating MCDM Challenges Under t-Intuitionistic Fuzzy Environments

IEEE Access
The significance of t-intuitionistic fuzzy TOPSIS lies in its ability to address challenges related to uncertainty and ambiguity within the decision-making process.
Dilshad Alghazzawi, Hanan Alolaiyan, Laila Latif, Umer Shuaib, Hamiden Abd El-Wahed Khalifa, Haifa Alqahtani, Qin Xin   +6 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A Theoretical Development on Fuzzy Distance Measure

Journal of Mathematical Extension, 2015
Fuzzy distance measure is one of the most useful tools in applications. Many distance methods have been proposed so far. However, there is no method that can always give a satisfactory solution to every situation.
M. Alibeigi∗, E. Ghasem Khani, T. Hajjari   +2 more
doaj  

The Development of a Hybrid Model for Dam Site Selection Using a Fuzzy Hypersoft Set and a Plithogenic Multipolar Fuzzy Hypersoft Set

Foundations
Inrecent years, there has been a notable increase in utilising multiple criteria decision-making (MCDM) methods in practical problem solving. The advancement of enhanced decision models with greater capabilities, coupled with technologies like geographic
Sheikh Zain Majid, Muhammad Saeed, Umar Ishtiaq, Ioannis K. Argyros   +3 more
doaj   +1 more source