Results 121 to 130 of about 4,918,184 (297)
Fermat Distance-to-Measure: a robust Fermat-like metric
Given a probability measure with density, Fermat distances and density-driven metrics are conformal transformations of the Euclidean metric that shrink distances in high density areas and enlarge distances in low density areas.Although they have been ...
Taupin, Jérôme, Chazal, Frédéric
core +4 more sources
Journal of New Theory, 2020 Clustering plays an important role in data mining, pattern recognition and machine learning. This paper proposes Pythagorean neutrosophic clustering methods based on similarity measures between Pythagorean neutrosophic sets with T and F are dependent ...
Mohana Krıshnaswamy, Jansi Rajan
doaj
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Love Lives at a Distance: Distance Relationships over the Lifecourse [PDF]
Distance relationships may be increasingly undertaken by dual-career couples at some point in their life course. Although this can make it difficult to quantitatively measure, the extent of distance relating, qualitative analysis of distance ...
Mary Holmes
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Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
On the Commensurability of Directional Distance Functions [PDF]
Shephard’s distance functions are widely used instruments for characterizing technology and for estimating efficiency in contemporary economic theory and practice.
Salnykov, Mykhaylo, Zelenyuk, Valentin
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FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Management of Distance Education: IEC Modules
This report on Management of Distance Education consists of the following: Unit 11 Applying research to running an institution, UNIT 12 Assessment of distance education, UNIT 13 Managing the institution, UNIT 14 Budgeting and costs, UNIT 16 Managing ...
The Distance Education Centre of the University of the West Indies and The International Extension College
core
Exploring the use of distance education technology for lifestyle change
, 2011 Obesity affects over 100 million men, women, and children in North America alone and has reached what health professionals deem to be epidemic proportions.
Patrick J. Tierney
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