Results 51 to 60 of about 3,650,464 (284)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

An Integrated CODAS Method and Novel Surface-based Weighted Distance Measures under Neutrosophic Environment [PDF]

Neutrosophic Sets and Systems
Information theory provides suitable tools for solving practical problems, particularly multi-criteria decision-making (MCDM) problems under neutrosophic environments.
Madineh Farnam, Gholam Hassan Shirdel, Majid Darehmiraki   +2 more
doaj   +1 more source

A Divergence-Based Distance Measure for Intuitionistic Fuzzy Sets and Its Application in the Decision-Making of Innovation Management

IEEE Access, 2020
The theory of intuitionistic fuzzy set has attracted much attention because of its stronger ability in depicting and modeling uncertainty. Recent years, numbers of distance measures of intuitionistic fuzzy sets have been proposed to distinguish the ...
Fei Ju, Yongzhi Yuan, Ye Yuan, Wen Quan
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Similarity measures on cubic intuitionistic fuzzy sets [PDF]

Notes on IFS
The primary objective of this study is to develop a similarity measure on cubic intuitionistic fuzzy sets. First, we have proposed a series of similarity measures on cubic intuitionistic fuzzy sets based on the geometric model, set-theoretic approach ...
M. Priyadharshini, D. Jayanthi
doaj   +1 more source

On Representations of Divergence Measures and Related Quantities in Exponential Families

Entropy, 2021
Within exponential families, which may consist of multi-parameter and multivariate distributions, a variety of divergence measures, such as the Kullback–Leibler divergence, the Cressie–Read divergence, the Rényi divergence, and the Hellinger metric, can ...
Stefan Bedbur, Udo Kamps
doaj   +1 more source

Detecting independence of random vectors: generalized distance covariance and Gaussian covariance

, 2018
Distance covariance is a quantity to measure the dependence of two random vectors. We show that the original concept introduced and developed by Sz\'{e}kely, Rizzo and Bakirov can be embedded into a more general framework based on symmetric L\'{e}vy ...
Böttcher, Björn, Keller-Ressel, Martin, Schilling, René L.   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source