Results 61 to 70 of about 3,652,591 (284)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
The Hubble Tension in Our Own Backyard: DESI and the Nearness of the Coma Cluster
The Astrophysical Journal LettersThe Dark Energy Spectroscopic Instrument (DESI) collaboration measured a tight relation between the Hubble constant ( H _0 ) and the distance to the Coma cluster using the fundamental plane (FP) relation of the deepest, most homogeneous sample of early ...
Daniel Scolnic +10 more
doaj +1 more source
Optimization of Pinned Photodiode Pixels for High-Speed Time of Flight Applications
IEEE Journal of the Electron Devices Society, 2018 We discuss optimizations of pinned photodiode (PPD) pixels for indirect time of flight sensors. We focus on the transfer-gate and dumping gate regions optimization, on the PPD dimension and shape to assure fast lateral charge transfer and on the ...
Fabio Acerbi +7 more
doaj +1 more source
Mrk 1419 - a new distance determination
, 2012 Water vapor megamasers from the center of active galaxies provide a powerful tool to trace accretion disks at sub-parsec resolution and, through an entirely geometrical method, measure direct distances to galaxies up to 200 Mpc.
C. M. Violette Impellizzeri +7 more
core +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Entropy measures of distance matrix [PDF]
Discrete Mathematics Letters, 2022 Bünyamin Şahin, Abdulgani Şahin
doaj +1 more source
Distance, similarity and entropy measures of n-dimensional fuzzy sets
Mathematics in Applied Sciences and EngineeringAn $n$-dimensional fuzzy set generalizes other fuzzy structures and effectively addresses real-world problems by providing greater flexibility in assigning membership values through the selection of an arbitrarily large $n$.
Jomal Josen, Sunil Jacob John, T. Baiju
doaj +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source