Results 81 to 90 of about 5,294,124 (256)

Distributional measures of concept-distance: A task-oriented evaluation

open access: yes, 2006
We propose a framework to derive the distance between concepts from distributional measures of word co-occurrences. We use the categories in a published thesaurus as coarse-grained concepts, allowing all possible distance values to be stored in a concept–
Graeme Hirst, Saif Mohammad
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

ON NEUTROSOPHIC REFINED SETS AND THEIR APPLICATIONS IN MEDICAL DIAGNOSIS

open access: yesJournal of New Theory, 2015
− In this paper, we present some definitions of neutrosophic refined sets such as; union,intersection, convex and strongly convex in a new way to handle the indeterminate information andinconsistent information.
İrfan Deli   +2 more
doaj  

Divergence-Oriented Distance Measures for Complex Picture Fuzzy Information with Applications in Renewable Energy Source Selection and Decision Analysis

open access: yesAxioms
Distance measures play a crucial role in fuzzy decision-making, pattern recognition, and uncertainty modeling. However, some existing distance measures for Complex Picture Fuzzy Sets (CPiFSs) have shown limitations and may produce counterintuitive ...
Ziyad A. Alhussain, Rashid Jan
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Time Series Classification by Class-Specific Mahalanobis Distance Measures [PDF]

open access: yes, 2012
To classify time series by nearest neighbors, we need to specify or learn one or several distance measures. We consider variations of the Mahalanobis distance measures which rely on the inverse covariance matrix of the data.
Lemire, Daniel, Prekopcsák, Zoltán
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

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