Results 61 to 70 of about 1,881,033 (281)

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Efficient data collection for camera trap‐based density estimation: A preliminary assessment

Ecological Solutions and Evidence
Camera traps have great potential for generating wildlife insights by providing high resolution site‐specific data. Methods of data collection and analysis reliant on these tools for population density estimation can be relatively resource intensive ...
Bálint Ternyik, Jamie E. T. McKaughan, Russell A. Hill, Philip A. Stephens   +3 more
doaj   +1 more source

Road bias for deer density estimates at 2 national parks in Maryland

Wildlife Society Bulletin, 2011
Estimating the population density of deer is an essential task for public agencies that plan a herd reduction. Distance sampling has been increasingly utilized to estimate population density, and is used by the National Park Service to estimate white ...
William J. McShea, Chad M. Stewart, Laura Kearns, Scott Bates   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Integrating counts from rigorous surveys and participatory science to better understand spatiotemporal variation in population processes

Methods in Ecology and Evolution
Knowledge of variation in population processes (e.g. population growth) across broad spatiotemporal scales is fundamental to population ecology and critical for conservation decision‐making. Count data from rigorous surveys (e.g.
Qing Zhao, Quresh S. Latif, Bryan L. Nuse, David C. Pavlacky Jr., Christopher L. Kilner, T. Brandt Ryder, Christopher E. Latimer   +6 more
doaj   +1 more source

Estimating Key Largo woodrat abundance using spatially explicit capture–recapture and trapping point transects

Wildlife Society Bulletin, 2016
The Key Largo woodrat (Neotoma floridana smalli) is an endangered rodent with a restricted geographic range and small population size. Establishing an efficient monitoring program of its abundance has been problematic; previous trapping designs have not ...
Joanne M. Potts, Stephen T. Buckland, Len Thomas, Anne Savage   +3 more
doaj   +1 more source

Radio-controlled, sound-operated switch [PDF]

, 1974
Switch presently provides remote control switching, by radio signals, or pollution sampling devices. Can be used for remote weather station interrogation, firing of pyrotechnics, control of dangerous equipment, or control of device in location where it ...
Bryant, T. D., Soloman, D. W., Jr.
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source