Results 81 to 90 of about 1,870,807 (288)
DiversityTransect surveys and distance sampling are widely used to estimate wildlife population densities, but these methods can be biased when animals aggregate near features such as waterholes or other resources that occur along survey routes.
Erika P. Swenson +3 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Keep Your Distance: Determining Sampling and Distance Thresholds in Machine Learning Monitoring
, 2022 Machine Learning~(ML) has provided promising results in recent years across different applications and domains. However, in many cases, qualities such as reliability or even safety need to be ensured. To this end, one important aspect is to determine whether or not ML components are deployed in situations that are appropriate for their application ...
Al-Harith Farhad +5 more
openaire +2 more sources
Short-Distance Cutoffs in Curved Space
, 2004 It is shown that space-time may possess the differentiability properties of manifolds as well as the ultraviolet finiteness properties of lattices. Namely, if a field's amplitudes are given on any sufficiently dense set of discrete points this could ...
Kempf, Achim
core +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
A Test of the Mean Distance Method for Forest Regeneration Assessment [PDF]
, 2014 A new distance-based estimator for forest regeneration assessment, the mean distance method, was developed by combining ideas and techniques from the wandering quarter method, T-square sampling and the random pairs method.
Hung, I-Kuai +4 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Investigating distance effects on environmental values: A choice modelling approach [PDF]
This paper describes a Choice Modelling experiment set up to investigate the relationship between distance and willingness to pay for environmental quality changes. The issue is important for the estimation and transfer of benefits.
Giovanni B. Concu
core
ACO for continuous function optimization: a performance analysis [PDF]
, 2014 The performance of the meta-heuristic algorithms often depends on their parameter settings. Appropriate tuning of the underlying parameters can drastically improve the performance of a meta-heuristic. The Ant Colony Optimization (ACO), a population based
Abraham, Ajith +2 more
core