Results 101 to 110 of about 356,474 (267)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

EduDCM: A Novel Framework for Automatic Educational Dialogue Classification Dataset Construction via Distant Supervision and Large Language Models

Applied Sciences
Educational dialogue classification is a critical task for analyzing classroom interactions and fostering effective teaching strategies. However, the scarcity of annotated data and the high cost of manual labeling pose significant challenges, especially ...
Changyong Qi, Longwei Zheng, Yuang Wei, Haoxin Xu, Peiji Chen, Xiaoqing Gu   +5 more
doaj   +1 more source

Few Clean Instances Help Denoising Distant Supervision

, 2022
Existing distantly supervised relation extractors usually rely on noisy data for both model training and evaluation, which may lead to garbage-in-garbage-out systems. To alleviate the problem, we study whether a small clean dataset could help improve the quality of distantly supervised models.
Liu, Yufang, Huang, Ziyin, Wang, Yijun, Sun, Changzhi, Lan, Man, Wu, Yuanbin, Mou, Xiaofeng, Wang, Ding   +7 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Reinforcement Learning for Distantly Supervised Relation Extraction

IEEE Access, 2019
Relation extraction is a task of identifying semantic relations between entity pairs from plain text, which can benefit a lot of AI applications such as knowledge base construction and answer questioning. The distant supervision strategy is introduced to
Tingting Sun, Chunhong Zhang, Yang Ji, Zheng Hu   +3 more
doaj   +1 more source

Effective Distant Supervision for Temporal Relation Extraction

, 2020
A principal barrier to training temporal relation extraction models in new domains is the lack of varied, high quality examples and the challenge of collecting more. We present a method of automatically collecting distantly-supervised examples of temporal relations.
Zhao, Xinyu, Lin, Shih-ting, Durrett, Greg   +2 more
openaire   +2 more sources

Large Discourse Treebanks from Scalable Distant Supervision

, 2022
Discourse parsing is an essential upstream task in Natural Language Processing with strong implications for many real-world applications. Despite its widely recognized role, most recent discourse parsers (and consequently downstream tasks) still rely on small-scale human-annotated discourse treebanks, trying to infer general-purpose discourse ...
Huber, Patrick, Carenini, Giuseppe
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Current Assessment of Some Extraterritorial Impacts of the Dodd-Frank Act with Special Focus on the Volcker Rule and Derivatives Regulation [PDF]

, 2012
As the world struggles to emerge from the Global Financial Crisis the vision of a harmonious framework of global financial regulation seems as distant as ever.
Baxter, Lawrence G.
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source