Results 81 to 90 of about 356,474 (267)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Cardinal Virtues: Extracting Relation Cardinalities from Text
, 2017 Information extraction (IE) from text has largely focused on relations between individual entities, such as who has won which award. However, some facts are never fully mentioned, and no IE method has perfect recall.
Darari, Fariz +3 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Reducing Wrong Labels for Distantly Supervised Relation Extraction With Reinforcement Learning
IEEE Access, 2020 Relation extraction (RE) aims to mine semantic relations between entity pairs from plain texts, which plays an important role in various natural language processing (NLP) tasks.
Tiantian Chen +3 more
doaj +1 more source
Cross-relation Cross-bag Attention for Distantly-supervised Relation Extraction
, 2018 Distant supervision leverages knowledge bases to automatically label instances, thus allowing us to train relation extractor without human annotations.
Liu, Liyuan +7 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Joint Extraction of Entities and Relations Based on a Novel Tagging Scheme
, 2017 Joint extraction of entities and relations is an important task in information extraction. To tackle this problem, we firstly propose a novel tagging scheme that can convert the joint extraction task to a tagging problem.
Bao, Hongyun +5 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
IEEE Access, 2019 Distant supervision (DS) has become an efficient approach for relation extraction (RE) to alleviate the lack of labeled examples in supervised learning. In this paper, we propose a novel neural RE model that combines a bidirectional gated recurrent unit ...
Van-Thuy Phi +5 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source