Results 71 to 80 of about 292 (213)

Improving Distantly Supervised Relation Classification With Attention and Semantic Weight

IEEE Access, 2019
Distantly supervised relation classification aims at identifying the relationship between two given entities and plays an essential part in natural language processing (NLP). Although distant supervision is able to generate labeled data automatically, it
Zhangdong Zhu, Jindian Su, Yang Zhou
doaj   +1 more source

Large-scale protein-protein post-translational modification extraction with distant supervision and confidence calibrated BioBERT

BMC Bioinformatics, 2022
Motivation Protein-protein interactions (PPIs) are critical to normal cellular function and are related to many disease pathways. A range of protein functions are mediated and regulated by protein interactions through post-translational modifications ...
Aparna Elangovan, Yuan Li, Douglas E. V. Pires, Melissa J. Davis, Karin Verspoor   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

FGSI: distant supervision for relation extraction method based on fine-grained semantic information

Scientific Reports, 2023
Relation extraction is one of the important steps in building a knowledge graph. Its main objective is to extract semantic relationships from identified entity pairs in sentences, playing a crucial role in semantic understanding and knowledge graph ...
Chenghong Sun, Weidong Ji, Guohui Zhou, Hui Guo, Zengxiang Yin, Yuqi Yue   +5 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Improving Distantly Supervised Relation Extraction with Multi-Level Noise Reduction

AI
Background: Distantly supervised relation extraction (DSRE) aims to identify semantic relations in large-scale texts automatically labeled via knowledge base alignment.
Wei Song, Zijiang Yang
doaj   +1 more source

Subsequence and distant supervision based active learning for relation extraction of Chinese medical texts

BMC Medical Informatics and Decision Making, 2023
In recent years, relation extraction on unstructured texts has become an important task in medical research. However, relation extraction requires a large amount of labeled corpus, manually annotating sequences is time consuming and expensive. Therefore,
Qi Ye, Tingting Cai, Xiang Ji, Tong Ruan, Hong Zheng   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

EduDCM: A Novel Framework for Automatic Educational Dialogue Classification Dataset Construction via Distant Supervision and Large Language Models

Applied Sciences
Educational dialogue classification is a critical task for analyzing classroom interactions and fostering effective teaching strategies. However, the scarcity of annotated data and the high cost of manual labeling pose significant challenges, especially ...
Changyong Qi, Longwei Zheng, Yuang Wei, Haoxin Xu, Peiji Chen, Xiaoqing Gu   +5 more
doaj   +1 more source