Results 111 to 120 of about 3,102,738 (289)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Yueju – The Formation of a Legitimate Culture in Contemporary Shanghai

open access: yesCulture Unbound: Journal of Current Cultural Research, 2012
This article presents a case study of the development of a local cultural form – Shanghai Yueju – caught up in the rapid urban redevelopment of post-socialist China.
Haili Ma
doaj   +1 more source

Causation and the Law: Preemption, Lawful Sufficiency, and Causal Sufficiency [PDF]

open access: yes, 2001
This article briefly describes the normative/nonnormative distinction, and how one might invoke this distinction to locate a nonnormative dimension of actual causation. After briefly introducing Richard Wright\u27s concept of a necessary element in a set
Fumerton, Richard, Kress, Ken
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Couchsurfing : la distinction touristique par la rencontre

open access: yesTéoros, 2017
Comme de nombreux autres domaines de l’activité humaine, le secteur du tourisme est modifié par les nouvelles possibilités technologiques. L’avènement de réseaux d’hospitalité, dont le plus connu est Couchsurfing, atteste de l’enthousiasme des voyageurs ...
Pauline Neveu
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Légitimité, omnivorité et éclectisme: goûts et dégoûts en matière d’ameublement et de décoration domestique. Etude qualitative auprès de jeunes représentants des classes moyennes supérieures

open access: yesSwiss Journal of Sociology, 2018
La théorie de la légitimité culturelle telle que proposée par Pierre Bourdieu a suscité de nombreuses critiques, qui ont donné lieu à de nouveaux développements théoriques.
Ischer Patrick
doaj   +1 more source

What our Rylean Ancestors Knew:\ud More on Knowing How and Knowing That [PDF]

open access: yes, 2003
In their recent article "Knowing How,�1 Jason Stanley and\ud Timothy Williamson deny that there is a fundamental\ud distinction between knowing-how and knowing-that,\ud claiming instead that knowledge-how is rather a form of\ud knowledge-that.
Shieber, Joseph
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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