Results 111 to 120 of about 957,207 (251)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The nobiliary concept of play as a mechanism for ethical-political distinction in the Late Middle Ages. (El imaginario lúdico de la nobleza como dispositivo de la distinción ético-política en la Baja Edad Media Occidental). [PDF]
Revista Internacional de Ciencias del Deporte, 2008 This article examines the problematic meaning, both in concept and practice, of games in the late Middle Ages, using Norbert Elias’ theoretical perspective of the civilizing process.
Manuel Rodríguez López +1 more
doaj
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
KANT’IN TEORİK AKIL-PRATİK AKIL AYRIMINA ELEŞTİREL BİR YAKLAŞIM
Felsefe Dünyası, 2020 Kant’ın düşünce sistemi hissetme ile düşünme yetileri arasında yaptığı ayrım üzerinde yükselir. Bu ayrım Kant tarafından temellendirilmemiştir; sistemin bütünü bakımından bir hipotez niteliğindedir.
Aliye Kovanlıkaya
doaj
Quasi-Formal Real Immanent Distinction (QFRID) [PDF]
I propose the discovery of a new metaphysical distinction: Quasi-Formal Real Immanent Distinction (QFRID). Developed through a structural reevaluation of Thomas Aquinas’ Real Distinction, QFRID emerges when the participatory element (Actus Essendi) is ...
Mea, Filiocaelo Neo F.
core
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source