Results 41 to 50 of about 3,888,731 (300)

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

open access: yesScience, 2018
Taking CRISPR technology further CRISPR techniques are allowing the development of technologies for nucleic acid detection (see the Perspective by Chertow).
J. Gootenberg   +5 more
semanticscholar   +1 more source

Labour Market Mismatches in the EU and OECD Countries [PDF]

open access: yesRevista Română de Statistică, 2011
The paper discusses labour market mismatches from the perspective of models commonly used for their analysis: matching functions and Beveridge curve.
Gina Cristina DIMIAN
doaj  

Recent Advances on GaN-Based Micro-LEDs

open access: yesMicromachines, 2023
GaN-based micro-size light-emitting diodes (µLEDs) have a variety of attractive and distinctive advantages for display, visible-light communication (VLC), and other novel applications.
Youwei Zhang   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Methodological approaches to risk assessment of real investment projects

open access: yesMATEC Web of Conferences, 2018
Risk management is impossible without systematically assessing the level of significance of the risks identified in the project. Within the scope of the paper, the distinctive features of various qualitative and quantitative methods for assessing the ...
Bogomolova Ekaterina
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Mixotrophic cyanobacteria and microalgae as distinctive biological agents for organic pollutant degradation.

open access: yesEnvironment International, 2013
Millions of natural and synthetic organic chemical substances are present in both soil and aquatic environments. Toxicity and/or persistence determine the polluting principle of these substances.
S. Subashchandrabose   +4 more
semanticscholar   +1 more source

RISK MANAGEMENT IN THE IMPLEMENTATION OF INVESTMENT AND CONSTRUCTION PROJECTS

open access: yesВестник университета, 2017
The article examines the problem of risk management in the implementation of investment and construction projects, proposed a comprehensive classification of risks, as well as a risk management mechanism for construction organizations.
I. Sokol
doaj   +1 more source

Bioinspired Flexible and Programmable Negative Stiffness Mechanical Metamaterials

open access: yesAdvanced Intelligent Systems, 2023
Energy‐absorbing materials are widely used under certain high‐frequency scenarios, such as cargo packaging or sport protection. Though negative stiffness mechanical metamaterials have many distinctive advantages, fairly low strength and poor specific ...
Xiaojun Tan   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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