Results 51 to 60 of about 1,665,556 (298)

Distinct role of the right temporoparietal junction in advantageous and disadvantageous inequity: A tDCS study

open access: yesFrontiers in Behavioral Neuroscience, 2023
Fairness is a hallmark of humans' ability to maintain cooperative relationships with large numbers of unrelated others. It influences many aspects of daily life, from how people share their resources with partners to how policymakers shape income distribution policy.
Shijing Wu   +7 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ABOUT “LEGITIMIZATION” OF NUMERICAL MODELLING OF WIND IMPACTS ON BUILDINGS AND STRUCTURES IN DESIGN CODES

open access: yesInternational Journal for Computational Civil and Structural Engineering, 2019
The distinctive paper is detoded to problem of “legitimization” of numerical modelling of wind loads and impacts on buildings and structures. General information about computational fluid dynamics (CFD) and its development prospects is presented.
Alexander Belostotsky   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

The distinctive nature of music education and music teacher education [PDF]

open access: yes, 2001
[Abstract]: To become a music teacher in Queensland secondary schools, it is necessary to qualify at tertiary level. The coursework paths that preservice teachers take prior to graduating as music teachers are found within the accredited education ...
Ballantyne, Julie
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Ultrasonic field-assisted metal additive manufacturing (U-FAAM): Mechanisms, research and future directions

open access: yesUltrasonics Sonochemistry
Metal additive manufacturing (AM) is a disruptive technology that provides unprecedented design freedom and manufacturing flexibility for the forming of complex components.
Xuekai Li   +9 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Nanomaterial: a neglected bioink ingredient for 3D printing of biomineralization-enabled structural composites

open access: yesFrontiers in Mechanical Engineering
In the past decades, biomineralization-enabled structural composites with self-healing and self-growing properties have attracted significant amounts of attention from the research community.
Congrui Jin   +3 more
doaj   +1 more source

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