Results 51 to 60 of about 538,572 (295)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

RISK MANAGEMENT IN THE IMPLEMENTATION OF INVESTMENT AND CONSTRUCTION PROJECTS

Вестник университета, 2017
The article examines the problem of risk management in the implementation of investment and construction projects, proposed a comprehensive classification of risks, as well as a risk management mechanism for construction organizations.
I. Sokol
doaj   +1 more source

E-portfolio thinking in teacher training: a small-scale study in K-12 in Turkey [PDF]

, 2008
The account given in this paper is related to the experiences of foreign language teachers involved in the pilot study undertaken in a high school in Turkey. After outlining the distinctive advantages of e-portfolios in the context of teacher development;
Kok, Ayse
core  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Letter processing and font information during reading: beyond distinctiveness, where vision meets design [PDF]

, 2012
Letter identification is a critical front end of the reading process. In general, conceptualizations of the identification process have emphasized arbitrary sets of distinctive features.
A Arditi, AI Rudnicky, BJ Juhasz, CJ Davis, CS Martin, D Adams, D Besner, D Fiset, D Fiset, D LaBerge, D Marr, D Navon, D Spinelli, DD Wheeler, DE Broadbent, DE Knuth, DG Paterson, DG Pelli, DG Pelli, DG Pelli, DG Pelli, DW Massaro, DW Massaro, DWJ Corcoran, E Johnston, EJ Gibson, G Keren, GC Gilmore, GC Oden, GC Oden, GC Oden, GM Reicher, GR Lockhead, GR Lockhead, GW Humphreys, H Bouma, H Spencer, I Biederman, I Gauthier, J Grainger, J Grainger, J Harris, J Miller, J Pittman, JA Stuart, JH Neely, JL McClelland, JL McClelland, K Cheng, K Mayall, LM Ward, M Finkbeiner, MA Changizi, MA Changizi, MA Tinker, MA Tinker, Mary C. Dyson, MC Mozer, MJ Gervais, P Baines, P Gomez, P Luna, P Walker, PA Kolers, PHK Seymour, R Carter, R Friedman, S Beier, S Pinker, S Sternberg, SD Goldinger, SE Palmer, SJ White, SN Lanthier, STL Chung, T Sanocki, T Sanocki, T Sanocki, T Sanocki, T Sanocki, T Sanocki, T Sanocki, T Sanocki, T Sanocki, Thomas Sanocki, TM Nearey, WP Tanner Jr, X Gao   +87 more
core   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Enumerating Counter-Factual Type Error Messages with an Existing Type Checker (poster+demo) [PDF]

, 2014
The Hindley-Milner type system is a foundation for most statically typed functional programming languages, such as ML, OCaml and Haskell. This type system has many advantageous, but it does make type debugging hard: If a program is not well-typed, it ...
Chitil, Olaf, Tsushima, Kanae
core  

The Instruments of Place Branding: How is it Done? [PDF]

, 2009
Place branding is the idea of discovering or creating some uniqueness, which differentiates one place from others in order to gain a competitive brand value.
Ashworth, Gregory
core   +1 more source